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Viewing lesions using a dermatoscope helps the dermatologist distinguish between benign and malignant lesions. It is particularly useful in the early diagnosis of melanoma, which is the fastest growing cancer in the US and worldwide. This issue of the Dermatologic Clinics issue all of the important topics in dermoscopy, including differentiation of lesions, lesions in the young and older populations, and dermoscopy in general dermatology.