Currently used proteomics methods can provide global analyses of expressed proteins in specific mammalian cells and tissues. Recent progress in tissue isolation, protein separation, quantification, sequence analysis, and structural and interaction proteomics offers great promise for bringing periodontal physiology and pathology into the modern era. This book elaborates the currently available techniques, their reported applications for periodontal tissues. Furthermore, the current status of periodontal proteomic analysis and the discovered biomarkers.