Ashutosh Tiwari, Hirak K. Patra, Jeong-Woo Choi

Advanced Theranostic Materials

Herausgeber: Tiwari, Ashutosh; Choi, Jeong-Woo; Patra, Hirak K

• Gebundenes Buch

Produktbeschreibung

The present book is covers the recent advances in the development on the regulation of such theragnosis system and their biomedical perspectives to act as a future nanomedicine. Advanced Theranostics Materialsis written by a distinguished group of contributors and provides comprehensive coverage of the current literature, up-to-date overview of all aspects of advanced theranostics materials ranging from system biology, diagnostics, imaging, image-guided therapy, therapeutics, biosensors, and translational medicine and personalized medicine, as well as the much broader task of covering most topics of biomedical research. The books focusses on the following topics:

Part 1: System biology and translational medicine
Aberrant Signaling Pathways: Hallmark of Cancer Cells and Target for Nanotherapeutics
Application of Nanoparticles in Cancer Treatment
Biomacromolecule-Gated Mesoporous Silica Drug Delivery Systems
Construction of Functional DNA Nanostructures for Theranostic Applications
Smart Polypeptide Nanocarriers for Malignancy Therapeutics

Part 2: Imaging and therapeutics

Dimercaptosuccinic acid-coated magnetic nanoparticles as a localized delivery system in cancer immunotherapy
Cardiovascular nanomedicine
Chitosan-based systems for sustained drug release
Nanocapsules in biomedicine: promises and challenges
Chitosan-based polyelectrolyte complexes: characteristics and application in
formulation of particulate drug carriers

Part 3: Diagnostics and featured prognostics

Non-invasive Glucose Biosensors based on Nanomaterials
Self/directed Assembly of Nanoparticles: A review on various approaches
Ion exchangers - an open window for the development of advanced materials with pharmaceutical and medical applications
New Titanium Alloys for Biomedical Applications

Produktdetails

• Advance Materials Series
• Verlag: Wiley & Sons
• 1. Auflage
• Seitenzahl: 360
• Erscheinungstermin: 3. August 2015
• Englisch
• Abmessung: 236mm x 157mm x 23mm
• Gewicht: 612g
• ISBN-13: 9781118998298
• ISBN-10: 1118998294
• Artikelnr.: 41562603

Autorenporträt

Prof. Ashutosh Tiwari is Managing Director, Tekidag AB and Group leader, Smart Materials and Biodevices at the Biosensors and Bioelectronics Centre, Linköping University, Sweden; Editor-in-Chief, Advanced Materials Letters; Secretary General, International Association of Advanced Materials; a materials chemist and also a docent in applied physics from Linköping University, Sweden. He has published more than 425 articles, patents, and conference proceedings in the field of materials science and technology and has edited/authored about 25 books on the advanced state-of-the-art of materials science and technology. He is a founding member of the Advanced Materials World Congress, Smart Materials and Surfaces, Korean Advanced Materials World Congress, African Advanced Materials World Congress, European Graphene Forum and the World Technology Forum. Jeong-Woo Choi is a Professor at Department of Chemical & Biomolecular Engineering and a director of Institute of Integrated Biotechnology, Sogang University, South Korea. He received Ph. D. in Rutgers University (USA), D.Eng. in Tokyo Institute of Technology (Japan) and MBA in University of Durham (UK); a visiting scientist in IBM Almaden Research Center and Mitsubishi Electronics Advanced Technology R&D Center. He is an editorial member of Biochip Journal, Biotechnology & Bioprocess Engineering, and J. Ind. & Eng. Chem. He has published more than 340 articles in peer-reviewed international journals and 46 patents in biosensor and bioelectronics fields, and he has edited/authored fifteen books on biosensor and advanced biomaterials.

Inhaltsangabe

Preface xiii Part 1: System Biology and Translational Medicine 1 Aberrant
Signaling Pathways 3 Gulnaz T. Javan, Sheree J. Finley, Ismail Can,
Amandeep Salhotra, Ashinm Malhotra, and Shivani Soni 1.1 Cancer 4 1.2
Pathways Deregulated in Cancer: Introduction 4 1.3 Introduction to
Nanotechnology 6 1.3.1 Overview of Clinical Nanotechnology 9 1.3.2 Current
Usage in Cancer Treatment 13 1.4 Current Uses in Cancer Diagnostic 14 1.4.1
The Phosphatidylinositol 3-Kinase-AKT Pathway 15 1.4.2 The MAPK Pathway 18
1.4.3 mTOR Pathway 20 1.4.4 Receptor Tyrosine Kinase 23 Acknowledgment 26
References 27 2 Application of Nanoparticles in Cancer Treatment 37 Behnoud
Hormozi 2.1 Introduction 38 2.1.1 Nanotechnology 38 2.1.2 Nanobiotechnology
38 2.1.3 Nanotechnology in Medicine 39 2.1.4 Cancer and Nano in Medicine 41
2.2 Nanoparticles in Cancer Treatment 41 2.3 Nanoparticle Platforms as Drug
Delivery Systems for Cancer Therapy 43 2.3.1 Lipid-based Nanoparticle
Platforms 44 2.3.2 Polymer-based Nanoparticle Platforms 45 2.3.3
Protein-based Nanoparticle Platforms 47 2.3.4 Inorganic Nanoparticle
Platforms 47 2.4 Theranostic Nanomedicine 50 2.4.1 Theranostic Nanomedicine
for Cancer Therapy 54 2.5 Selective Drug Delivery and Encapsulation for
Chemotherapy 54 2.6 Stimuli-Sensitive Nanopreparations 55 2.7
Multifunctional Nanopreparations 56 2.8 Cancer Nanotechnology: Future and
Challenges 58 References 59 3 Biomacromolecule-Gated Mesoporous Silica Drug
Delivery Systems for Stimuli-Responsive Controlled Release 67 Xuezhong Du
3.1 Introduction 68 3.2 Protein-Gated MSN Drug Delivery Systems 69 3.2.1
Ligand-Binding Protein-Gated MSN Systems 70 3.2.2 Metal-Chelating
Protein-Gated MSN Systems 74 3.3 DNA-Gated MSN Drug Delivery Systems 75
3.3.1 Single-Stranded DNA-Gated MSN Systems 76 3.3.2 Double-Stranded
DNA-Gated MSN Systems 77 3.3.3 Hairpin or Quadruplex DNA-Gated MSN Systems
80 3.3.4 Native DNA-Gated MSN Systems 83 3.3.5 Near-Infrared
Light-Triggered DNA-Gated MSN Systems 87 3.4 Conclusions and Perspectives
89 Acknowledgments 90 References 90 4 Construction of Functional DNA
Nanostructures for Theranostic Applications 93 Jiang Li, Fan Li, Hao Pei,
Lihua Wang, Qing Huang, and Chunhai Fan 4.1 The Progress of Structural DNA
Nanotechnology 94 4.2 DNA Nanostructures for Diagnostics 96 4.3 DNA
Nanostructures for Diagnostics on the Interface 96 4.4 Diagnostic in
Homogeneous Solution 99 4.4.1 Spherical Nucleic Acids (SNA) Probes for
Detections in Solution 99 4.4.2 Nanochips in Solution 100 4.4.3
Intracellular/In Vivo Diagnosis 103 4.5 DNA Nanostructures for Therapeutics
106 4.5.1 Delivery of Small-Molecular Drugs 107 4.5.2 Delivery of CpG DNAs
109 4.5.3 RNA Interference (RNAi) 111 4.5.4 Delivery of Proteins 114 4.6
Integration of Diagnosis and Therapy: Smart DNA Theranostic Nanodevices 115
4.7 Targeted Delivery 115 4.8 Controlled/Triggered Release 117 4.9 Summary
and Perspectives 119 4.9.1 The Bioeffects of DNA Nanostructures 119 4.9.2
Purity and Yield 120 4.9.3 Dynamic Structures for Theranostic 120
References 121 Part 2: Imaging and Therapeutics 5 Dimercaptosuccinic
Acid-Coated Magnetic Nanoparticles as a Localized Delivery System in Cancer
Immunotherapy 133 Raquel Mejías, Lucía Gutiérrez, María P. Morales, and
Domingo F. Barber 5.1 Introduction 134 5.1.1 Nanoparticle-based Drug
Delivery Systems 134 5.1.2 Nanoparticles for Drug Delivery in Cancer
Treatment 135 5.1.3 Magnetic Nanoparticles (MNP) 135 5.1.4 Nanoparticle
Biodistribution and Degradation 136 5.2 Nanoparticle Detection and
Quantification: In Vitro and In Vivo Techniques 137 5.2.1 Optical
Microscopy 137 5.2.2 Colorimetric Assays 137 5.2.3 Transmission Electron
Microscopy 138 5.2.4 Magnetic Methods 140 5.2.5 Elemental Analysis 142
5.2.6 Nuclear Magnetic Resonance (NMR) 143 5.3 Evaluation of
Nanoparticle-Induced Toxicity 143 5.3.1 In Vitro Toxicity 143 5.4 Magnetic
Targeting of Nanoparticles 147 5.5 A Specific Example: DMSA-Coated Magnetic
Nanoparticles 148 5.5.1 In Vitro DMSA-MNP Uptake and Intracellular
Localization 148 5.5.2 In Vitro DMSA-MNP Toxicity 149 5.5.3 In Vitro
DMSA-MNP-Induced Cell Stress and Apoptosis 150 5.5.4 In Vivo DMSA-MNP
Distribution 150 5.5.5 In Vivo DMSA-MNP-Induced Toxicity 152 5.5.6 In Vivo
DMSA-MNP Biotransformation 152 5.6 Conclusions 153 Acknowledgments 154
References 154 6 Cardiovascular Nanomedicine 159 Suryyani Deb and Hirak
Kumar Patra 6.1 Introduction 160 6.2 Nanoscale Cardiovascular Diagnostics
160 6.2.1 Cardiac Molecular Biomarker Detection from Peripheral Blood 161
6.2.2 Diagnosis through Nano-based Molecular Imaging 163 6.2.3
Determination of Stem Cell Delivery 165 6.3 Nanotechnology in
Cardiovascular Therapeutics 167 6.3.1 Drug Delivery 167 6.3.2 Gene Delivery
169 6.3.3 Tissue Engineering 169 6.4 Nanotechnology in the Surgery of
Cardiovascular Disease 170 6.5 Conclusion 172 References 173 7
Chitosan-based Interpenetrating Polymeric Network Systems for Sustained
Drug Release 183 Amit Kumar Nayak and Dilipkumar Pal 7.1 Introduction 184
7.2 IPNs and Their Uses in Drug Delivery 185 7.3 Chitosan 187 7.4
Chitosan-Tamarind Seed Polysaccharide IPN Microparticles and Matrix Tablets
for Sustained Release of Aceclofenac 189 7.5 Chitosan-Hydroxyethyl
Cellulose IPN Microspheres of Isoniazid 193 7.6 Chitosan-Methyl Cellulose
IPN Microspheres of Theophylline 194 7.7
Chitosan-Acrylamide-Grafted-Poly(Vinyl Alcohol) and Hydrolyzed
Acrylamide-Grafted-Poly(Vinyl Alcohol) IPN Microgels of Cefadroxil 198 7.8
Chitosan-Poly(N-Isopropylacrylamide) IPN Discs of Diclofenac Sodium 199 7.9
Chitosan-Poly(Ethylene Oxide-Grafted-Acrylamide) Semi-IPN Hydrogel
Microspheres of Capecitabine 200 7.10 Acrylamide-Grafted Dextran-Chitosan
Semi-IPN Microspheres of Acyclovir 201 7.11 Chitosan-Acrylamide-Grafted
Hydroxyethylcellulose Semi-IPN Microspheres of Diclofenac Sodium 202 7.12
Poly [N-Acryloylglycine-Chitosan] IPN Hydrogel of 5-Fluorouracil 202 7.13
Chitosan-N,N'-Dimethylacrylamide Semi-IPN Microspheres of Chlorothiazide
203 7.14 Conclusion 203 References 204 8 Nanocapsules in Biomedicine 209
Frank J. Hernandez, Murat Kavruk, Luiza I. Hernandez, and Veli C. Ozalp 8.1
Nanocapsules: A Novel Nano-Drug Delivery System 210 8.2 Magic Bullets:
Nanocapsules in Future Medicine 211 8.3 In Vitro Applications of
Nanocapsules 212 8.3.1 Functionalized Mesoporous Silica Materials for
Controlled Drug Delivery 212 8.3.2 Cationic Polymer Nanocapsules for
Controlled Multi-drug Delivery 220 8.3.3 Lipid Nanocapsules 221 8.4 In Vivo
Applications of Nanocapsules 224 8.4.1 In Vivo Diagnostic Imaging 225 8.4.2
In Vivo Therapeutics 226 8.5 Conclusions 228 References 228 9
Chitosan-based Polyelectrolyte Complexes 235 Bojan Èalija, Nebojsa Cekiæ,
and Jela Miliæ 9.1 Introduction 236 9.2 Chitosans: Chemical Structure,
Physicochemical Properties, and Toxicological and Regulatory Aspects 237
9.2.1 Chemical Structure and Source 237 9.2.2 Physicochemical Properties
238 9.2.3 Toxicological and Regulatory Aspects 239 9.3 Polyelectrolyte
Complexes: Theoretical Background, Structure, and Basic Properties 240 9.4
Chitosan-based Polyelectrolyte Complexes in Particulate Drug Carriers 242
9.4.1 PECs Comprised of Chitosans and Natural or Semisynthetic Polyanions
243 9.4.2 PECs Comprised of Chitosans and Synthetic Polyanions 249 9.4.3
Influence of Chitosans Functional Properties and Experimental Conditions on
Polyelectrolyte Complexation 254 9.5 Characterization of Chitosan-Based
PECs and Chitosan-based PEC Particulate Drug Carriers 258 9.5.1 Size and
Morphology 258 9.5.2 Zeta Potential 259 9.5.3 Structural Analysis 259 9.5.4
Encapsulation Efficiency and Drug Loading Capacity 261 9.5.5 In Vitro
Swelling Studies 262 9.5.6 In Vitro Drug Release Studies 263 9.6 Conclusion
263 Acknowledgment 264 References 264 Part 3: Diagnostics and Featured
Prognostics 10. Non-invasive Glucose Biosensors Based on Nanomaterials 273
Farnoush Faridbod, Mohammad Reza Ganjali, Bagher Larijani and Parviz
Norouzi 10.1 Diabetes and Its Prevalence 274 10.2 Importance of Glucose
Monitoring 274 10.3 Glucose Measurement Methods 275 10.4 Non-invasive
Glucose Determination 275 10.4.1 Non-invasive Glucose Determination Using
Tissues 276 10.4.2 Non-invasive Glucose Determination Method Using Fluids
277 10.5 Glucose Biosensors 279 10.6 New Generation of Non-invasive Glucose
Biosensors-Based Nanomaterials 281 10.7 Future Perspective in Glucose
Monitoring 290 10.8 Conclusion 292 References 292 11 Self-Directed Assembly
of Nanoparticles 297 Arun Prakash Upadhyay, Dilip Kumar Behara, Gyan
Prakash Sharma, Raj Ganesh S. Pala, and Sri Sivakumar 11.1 Introduction 297
11.2 Self-Assembly through Molecular Interactions/Forces 298 11.2.1 Van der
Waals Interactions 298 11.2.2 Electrostatic Interaction 301 11.3
Hydrogen-Bonding Interactions 304 11.3.1 Covalent Interactions 306 11.3.2
DNA-Based Cross-Linking Interactions 311 11.4 Directed Self-Assembly by
External Forces 315 11.4.1 Magnetic Field-Driven Directed Self-Assembly 315
11.4.2 Electric Field-Driven Directed Self-Assembly 319 11.4.3 Flow
Field-Driven Directed Self-Assembly 321 11.5 Conclusion 325 Acknowledgment
326 References 326 Index 337