Jerome Zoeller

Synthetic Sequences in Organic Chemistry (eBook, PDF)

• Format: PDF

Produktbeschreibung

Chemists faced with the need to make a compound often have minimal exposure to the synthetic literature. Even synthetic experts do not have every reaction at the tips of their fingers. This unique volume contains an enormous range of synthetic reactions from real examples.

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Produktdetails

• Verlag: Taylor & Francis
• Seitenzahl: 194
• Erscheinungstermin: 15. September 2023
• Englisch
• ISBN-13: 9781000904963
• Artikelnr.: 68687748

Autorenporträt

Jerome Zoeller graduated from Rensselaer Polytechnic Institute, USA, with a B.S. in Chemistry and began work at the Rohm & Haas Co. in applications and pro-cess development with acrylic polymers. Graduate study followed at the University of Texas, USA, with research concentration in physical organic chemistry. Upon completing the Ph.D. program, he went on for two years as a Postdoctoral Research Fellow in the use of organometallics in synthetic and structural studies. At the Southwest Foundation for Research and Education he developed preparative methods for cortisol analogs, and their use in affinity chromatography and primate brain research. In this decade he lectured at Trinity University, USA. A change in career occurred in which he studied Fuel Science at The Pennsylvania State University, USA. This specialty was pursued at Texas A&M University, USA, in the use of specialized oxidative transformations in studies of fossil fuel structure. Upon retirement he moved to a startup pharma company, Targacept Inc., for synthetic work on nicotinic acetylcholine esterase ligands of potential neurological activity. Upon moving to Texas, he was prompted to compile some of the synthetic sequences displayed in the twenty-first century literature, for this book.

Inhaltsangabe

1. Non-Natural Oranic Compounds. 2. Structural Moieties and Functional Groups . 3. Natural Products. 4. Diversification and Simplification. 5. Name Reactions. 6. Variations on a Synthetic Sequence

Rezensionen

Jerome Zoeller's book, Synthetic Sequences in Organic Chemistry, follows in the tradition of E. J. Corey's The Logic of Organic Synthesis with examples from the literature that illustrate the synthesis of natural and non-natural organic compounds, the placement of "structural moieties" and functional groups, and how synthetic sequences are simplified and diversified using synthetic examples selected by the author. He also gives examples of twelve named reactions in selected syntheses that use them. The last chapter provides illustrations on "how an optimal synthetic scheme can be developed from a discovery synthesis using an original retrosynthetic design." This book provides useful examples through which synthetic strategies can be illustrated. They come from carefully selected recent examples provided by diverse original sources. Textual explanations are clear, and the ChemDraw illustrations make the synthetic steps easy to follow. This book offers interesting examples using modern synthetic methodology, great for those interested in organic synyjesis.

- Michael Doyle, Ph.D., The Rita and John Feik Distinguished University Chair in Medicinal Chemistry, The University of Texas at San Antonio