- Gebundenes Buch
- Merkliste
- Auf die Merkliste
- Bewerten Bewerten
- Teilen
- Produkt teilen
- Produkterinnerung
- Produkterinnerung
This state-of-the-art reference addresses lysophospholipids, a special kind of fat that has been found to have a growing number of receptors within the cell and has important, natural roles in the body including normal reproduction, development, maturation, and life. The book covers the biochemistry, interactions, and signaling of lysophospholipids as well as its potential for producing new therapies for a range of medically important human diseases. Bringing together current knowledge in lysophospholipid signaling, this book is a must-have for all academic, industrial, and medical school and hospital libraries.…mehr
Andere Kunden interessierten sich auch für
- Anthony K. CampbellIntracellular Calcium, 2 Volume Set337,99 €
- Nawin C. MishraIntroduction to Proteomics140,99 €
- Tilman GruneProtein Oxidation and Aging197,99 €
- Charles C. HongChemical Biology in Regenerative Medicine155,99 €
- Natanya CivjanChemical Biology164,99 €
- Roberta MasellaGlutathione and Sulfur Amino Acids in Human Health and Disease225,99 €
- Natural Products in Chemical Biology164,99 €
-
-
-
This state-of-the-art reference addresses lysophospholipids, a special kind of fat that has been found to have a growing number of receptors within the cell and has important, natural roles in the body including normal reproduction, development, maturation, and life. The book covers the biochemistry, interactions, and signaling of lysophospholipids as well as its potential for producing new therapies for a range of medically important human diseases. Bringing together current knowledge in lysophospholipid signaling, this book is a must-have for all academic, industrial, and medical school and hospital libraries.
Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
Produktdetails
- Produktdetails
- Verlag: Wiley & Sons
- 1. Auflage
- Seitenzahl: 812
- Erscheinungstermin: 1. April 2013
- Englisch
- Abmessung: 236mm x 163mm x 41mm
- Gewicht: 1270g
- ISBN-13: 9780470569054
- ISBN-10: 0470569050
- Artikelnr.: 35712661
- Herstellerkennzeichnung
- Libri GmbH
- Europaallee 1
- 36244 Bad Hersfeld
- 06621 890
- Verlag: Wiley & Sons
- 1. Auflage
- Seitenzahl: 812
- Erscheinungstermin: 1. April 2013
- Englisch
- Abmessung: 236mm x 163mm x 41mm
- Gewicht: 1270g
- ISBN-13: 9780470569054
- ISBN-10: 0470569050
- Artikelnr.: 35712661
- Herstellerkennzeichnung
- Libri GmbH
- Europaallee 1
- 36244 Bad Hersfeld
- 06621 890
JEROLD CHUN, MD, PhD, is a Professor at The Scripps Research Institute in La Jolla, California, and is a pioneer in the field of lysophospholipid signaling.
PREFACE ix
CONTRIBUTORS xi
1 LYSOPHOSPHATIDIC ACID (LPA) RECEPTOR SIGNALING 1
Hope Mirendil, Mu-En Lin, and Jerold Chun
2 SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTORS 41
Bongnam Jung and Timothy Hla
3 GLOBAL GENE EXPRESSION PROGRAM OF LYSOPHOSPHATIDIC ACID (LPA)-STIMULATED
FIBROBLASTS 61
Catelijne Stortelers and Wouter H. Moolenaar
4 IDENTIFICATION OF DIRECT INTRACELLULAR TARGETS OF SPHINGOSINE 1-PHOSPHATE
(S1P) 71
Nitai C. Hait, Sheldon Milstien, and Sarah Spiegel
5 LYSOPHOSPHOLIPID RECEPTOR SIGNALING PLATFORMS: THE RECEPTOR TYROSINE
KINASE-G PROTEIN-COUPLED RECEPTOR SIGNALING COMPLEX 85
Nigel J. Pyne and Susan Pyne
6 AUTOTAXIN: A UNIQUE ECTO-TYPE PYROPHOSPHODIESTERASE WITH DIVERSE
FUNCTIONS 103
Hiroshi Yukiura and Junken Aoki
7 STUDIES ON AUTOTAXIN SIGNALING IN ENDOCYTIC VESICLE BIOGENESIS AND
EMBRYONIC DEVELOPMENT USING WHOLE EMBRYO CULTURE AND ELECTROPORATION 121
Masayuki Masu, Seiichi Koike, Takuya Okada, and Kazuko Keino-Masu
8 STANDARDIZATION AND QUANTIFICATION OF LYSOPHOSPHATIDIC ACID COMPOUNDS BY
NORMAL-PHASE AND REVERSED-PHASE CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY 137
Jeff D. Moore, Shengrong Li, David S. Myers, Stephen B. Milne, H. Alex
Brown, and Walter A. Shaw
9 SPHINGOSINE KINASES: BIOCHEMISTRY, REGULATION, AND ROLES 153
Melissa R. Pitman, Kate E. Jarman, Tamara M. Leclercq, Duyen H. Pham, and
Stuart M. Pitson
10 FUNCTIONAL AND PHYSIOLOGICAL ROLES OF SPHINGOSINE 1-PHOSPHATE
TRANSPORTERS 185
Atsuo Kawahara and Tsuyoshi Nishi
11 LIPID PHOSPHATE PHOSPHATASES AND SIGNALING BY LYSOPHOSPHOLIPID RECEPTORS
201
Ganesh Venkatraman and David N. Brindley
12 LIPID PHOSPHATE PHOSPHATASES: RECENT PROGRESS AND ASSAY METHODS 229
Andrew J. Morris, Susan S. Smyth, Abdel K. Salous, and Andrew D. Renault
13 LYSOPHOSPHATIDIC ACID (LPA) SIGNALING AND CARDIOVASCULAR PATHOLOGY 265
Susan S. Smyth, Anping Dong, Jessica Wheeler, Manikandan Panchatcharam, and
Andrew J. Morris
14 SPHINGOSINE 1-PHOSPHATE (S1P) SIGNALING IN CARDIOVASCULAR PHYSIOLOGY AND
DISEASE 283
Bodo Levkau
15 SPHINGOSINE 1-PHOSPHATE (S1P) SIGNALING AND THE VASCULATURE 313
Christian Waeber
16 REGULATION OF THE NUCLEAR HORMONE RECEPTOR PPAR¿ BY ENDOGENOUS
LYSOPHOSPHATIDIC ACIDS (LPAS) 349
Ryoko Tsukahara, Tamotsu Tsukahara, and Gabor Tigyi
17 MECHANISMS AND MODELS FOR ELUCIDATING THE CARDIAC EFFECTS OF SPHINGOSINE
1-PHOSPHATE (S1P) 373
Shigeki Miyamoto, Sunny Yang Xiang, Nicole H. Purcell, and Joan Heller
Brown
18 NEURAL EFFECTS OF LYSOPHOSPHATIDIC ACID (LPA) SIGNALING 399
Nobuyuki Fukushima
19 WIDESPREAD EXPRESSION OF SPHINGOSINE KINASES AND SPHINGOSINE 1-PHOSPHATE
(S1P) LYASE SUGGESTS DIVERSE FUNCTIONS IN THE VERTEBRATE NERVOUS SYSTEM 419
H. Meng and V.M. Lee
20 LYSOPHOSPHATIDIC ACID AND NEUROPATHIC PAIN: DEMYELINATION AND LPA
BIOSYNTHESIS 433
Hiroshi Ueda
21 ROLE OF LYSOPHOSPHATIDIC ACID (LPA) IN BEHAVIORAL PROCESSES:
IMPLICATIONS FOR PSYCHIATRIC DISORDERS 451
Guillermo Estivill-Torrús, Luis Javier Santín, Carmen Pedraza, Estela
Castilla-Ortega, and Fernando Rodríguez de Fonseca
22 SPHINGOSINE 1-PHOSPHATE (S1P) SIGNALING AND LYMPHOCYTE EGRESS 475
Alejandra Mendoza, Lauren A. Pitt, and Susan R. Schwab
23 BIOLOGY REVEALED BY SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTOR GENE-ALTERED
MICE 489
Maria L. Allende, Mari Kono, Aikaterini Alexaki, Christina Giannouli, Jiman
Kang, Catherine C. Theisen, Eleanor L. Koerner, and Richard L. Proia
24 ROLE OF LYSOPHOSPHATIDIC ACID (LPA) IN THE INTESTINE 507
C. Chris Yun and Peijian He
25 LYSOPHOSPHOLIPID SIGNALING IN FEMALE AND MALE REPRODUCTIVE SYSTEMS 529
Xiaoqin Ye
26 THE GONADS AND THEIR MAGIC BULLET, LYSOPHOSPHATIDIC ACID: PHYSIOLOGICAL
AND TOXICOLOGICAL FUNCTIONS OF LYSOPHOSPHATIDIC ACID (LPA) IN FEMALE AND
MALE REPRODUCTIVE SYSTEMS 569
Lygia Therese Budnik, Bärbel Brunswig-Spickenheier, and Dieter Müller
27 LYSOPHOSPHOLIPID REGULATION OF LUNG FIBROSIS 587
Barry S. Shea and Andrew M. Tager
28 LYSOPHOSPHATIDIC ACID (LPA) SIGNALING AND BONE 609
Jean Pierre Salles, Sara Laurencin-Dalicieux, Françoise Conte-Auriol,
Fabienne Briand-Mésange, and Isabelle Gennero
29 LYSOPHOSPHATIDIC ACID (LPA) SIGNALING AND BONE CANCER 627
Olivier Peyruchaud, Marion David, Timothy L. Macdonald, and Kevin R. Lynch
30 UNDERSTANDING THE FUNCTIONS OF LYSOPHOSPHATIDIC ACID RECEPTORS IN CANCER
641
Nattapon Panupinthu and Gordon B. Mills
31 LYSOPHOSPHATIDIC ACID RECEPTORS IN CANCER 661
Abir Mukherjee, Jinhua Wu, Yongling Gong, and Xianjun Fang
32 LPA RECEPTOR SUBTYPES LPA1 AND LPA2 AS POTENTIAL DRUG TARGETS 681
Gretchen Bain and T. Jon Seiders
33 CLINICAL INTRODUCTION OF LYSOPHOSPHATIDIC ACID (LPA) AND AUTOTAXIN
ASSAYS 709
Yutaka Yatomi, Koji Igarashi, Kazuhiro Nakamura, Ryunosuke Ohkawa, Akiko
Masuda, Akiko Suzuki, Tatsuya Kishimoto, Hitoshi Ikeda, and Junken Aoki
34 ANTIBODIES TO BIOACTIVE LYSOPHOSPHOLIPIDS 737
Roger A. Sabbadini, Jonathan M. Wojciak, Kelli Moreno, James S. Swaney, and
Barbara Visentin
INDEX 753
CONTRIBUTORS xi
1 LYSOPHOSPHATIDIC ACID (LPA) RECEPTOR SIGNALING 1
Hope Mirendil, Mu-En Lin, and Jerold Chun
2 SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTORS 41
Bongnam Jung and Timothy Hla
3 GLOBAL GENE EXPRESSION PROGRAM OF LYSOPHOSPHATIDIC ACID (LPA)-STIMULATED
FIBROBLASTS 61
Catelijne Stortelers and Wouter H. Moolenaar
4 IDENTIFICATION OF DIRECT INTRACELLULAR TARGETS OF SPHINGOSINE 1-PHOSPHATE
(S1P) 71
Nitai C. Hait, Sheldon Milstien, and Sarah Spiegel
5 LYSOPHOSPHOLIPID RECEPTOR SIGNALING PLATFORMS: THE RECEPTOR TYROSINE
KINASE-G PROTEIN-COUPLED RECEPTOR SIGNALING COMPLEX 85
Nigel J. Pyne and Susan Pyne
6 AUTOTAXIN: A UNIQUE ECTO-TYPE PYROPHOSPHODIESTERASE WITH DIVERSE
FUNCTIONS 103
Hiroshi Yukiura and Junken Aoki
7 STUDIES ON AUTOTAXIN SIGNALING IN ENDOCYTIC VESICLE BIOGENESIS AND
EMBRYONIC DEVELOPMENT USING WHOLE EMBRYO CULTURE AND ELECTROPORATION 121
Masayuki Masu, Seiichi Koike, Takuya Okada, and Kazuko Keino-Masu
8 STANDARDIZATION AND QUANTIFICATION OF LYSOPHOSPHATIDIC ACID COMPOUNDS BY
NORMAL-PHASE AND REVERSED-PHASE CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY 137
Jeff D. Moore, Shengrong Li, David S. Myers, Stephen B. Milne, H. Alex
Brown, and Walter A. Shaw
9 SPHINGOSINE KINASES: BIOCHEMISTRY, REGULATION, AND ROLES 153
Melissa R. Pitman, Kate E. Jarman, Tamara M. Leclercq, Duyen H. Pham, and
Stuart M. Pitson
10 FUNCTIONAL AND PHYSIOLOGICAL ROLES OF SPHINGOSINE 1-PHOSPHATE
TRANSPORTERS 185
Atsuo Kawahara and Tsuyoshi Nishi
11 LIPID PHOSPHATE PHOSPHATASES AND SIGNALING BY LYSOPHOSPHOLIPID RECEPTORS
201
Ganesh Venkatraman and David N. Brindley
12 LIPID PHOSPHATE PHOSPHATASES: RECENT PROGRESS AND ASSAY METHODS 229
Andrew J. Morris, Susan S. Smyth, Abdel K. Salous, and Andrew D. Renault
13 LYSOPHOSPHATIDIC ACID (LPA) SIGNALING AND CARDIOVASCULAR PATHOLOGY 265
Susan S. Smyth, Anping Dong, Jessica Wheeler, Manikandan Panchatcharam, and
Andrew J. Morris
14 SPHINGOSINE 1-PHOSPHATE (S1P) SIGNALING IN CARDIOVASCULAR PHYSIOLOGY AND
DISEASE 283
Bodo Levkau
15 SPHINGOSINE 1-PHOSPHATE (S1P) SIGNALING AND THE VASCULATURE 313
Christian Waeber
16 REGULATION OF THE NUCLEAR HORMONE RECEPTOR PPAR¿ BY ENDOGENOUS
LYSOPHOSPHATIDIC ACIDS (LPAS) 349
Ryoko Tsukahara, Tamotsu Tsukahara, and Gabor Tigyi
17 MECHANISMS AND MODELS FOR ELUCIDATING THE CARDIAC EFFECTS OF SPHINGOSINE
1-PHOSPHATE (S1P) 373
Shigeki Miyamoto, Sunny Yang Xiang, Nicole H. Purcell, and Joan Heller
Brown
18 NEURAL EFFECTS OF LYSOPHOSPHATIDIC ACID (LPA) SIGNALING 399
Nobuyuki Fukushima
19 WIDESPREAD EXPRESSION OF SPHINGOSINE KINASES AND SPHINGOSINE 1-PHOSPHATE
(S1P) LYASE SUGGESTS DIVERSE FUNCTIONS IN THE VERTEBRATE NERVOUS SYSTEM 419
H. Meng and V.M. Lee
20 LYSOPHOSPHATIDIC ACID AND NEUROPATHIC PAIN: DEMYELINATION AND LPA
BIOSYNTHESIS 433
Hiroshi Ueda
21 ROLE OF LYSOPHOSPHATIDIC ACID (LPA) IN BEHAVIORAL PROCESSES:
IMPLICATIONS FOR PSYCHIATRIC DISORDERS 451
Guillermo Estivill-Torrús, Luis Javier Santín, Carmen Pedraza, Estela
Castilla-Ortega, and Fernando Rodríguez de Fonseca
22 SPHINGOSINE 1-PHOSPHATE (S1P) SIGNALING AND LYMPHOCYTE EGRESS 475
Alejandra Mendoza, Lauren A. Pitt, and Susan R. Schwab
23 BIOLOGY REVEALED BY SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTOR GENE-ALTERED
MICE 489
Maria L. Allende, Mari Kono, Aikaterini Alexaki, Christina Giannouli, Jiman
Kang, Catherine C. Theisen, Eleanor L. Koerner, and Richard L. Proia
24 ROLE OF LYSOPHOSPHATIDIC ACID (LPA) IN THE INTESTINE 507
C. Chris Yun and Peijian He
25 LYSOPHOSPHOLIPID SIGNALING IN FEMALE AND MALE REPRODUCTIVE SYSTEMS 529
Xiaoqin Ye
26 THE GONADS AND THEIR MAGIC BULLET, LYSOPHOSPHATIDIC ACID: PHYSIOLOGICAL
AND TOXICOLOGICAL FUNCTIONS OF LYSOPHOSPHATIDIC ACID (LPA) IN FEMALE AND
MALE REPRODUCTIVE SYSTEMS 569
Lygia Therese Budnik, Bärbel Brunswig-Spickenheier, and Dieter Müller
27 LYSOPHOSPHOLIPID REGULATION OF LUNG FIBROSIS 587
Barry S. Shea and Andrew M. Tager
28 LYSOPHOSPHATIDIC ACID (LPA) SIGNALING AND BONE 609
Jean Pierre Salles, Sara Laurencin-Dalicieux, Françoise Conte-Auriol,
Fabienne Briand-Mésange, and Isabelle Gennero
29 LYSOPHOSPHATIDIC ACID (LPA) SIGNALING AND BONE CANCER 627
Olivier Peyruchaud, Marion David, Timothy L. Macdonald, and Kevin R. Lynch
30 UNDERSTANDING THE FUNCTIONS OF LYSOPHOSPHATIDIC ACID RECEPTORS IN CANCER
641
Nattapon Panupinthu and Gordon B. Mills
31 LYSOPHOSPHATIDIC ACID RECEPTORS IN CANCER 661
Abir Mukherjee, Jinhua Wu, Yongling Gong, and Xianjun Fang
32 LPA RECEPTOR SUBTYPES LPA1 AND LPA2 AS POTENTIAL DRUG TARGETS 681
Gretchen Bain and T. Jon Seiders
33 CLINICAL INTRODUCTION OF LYSOPHOSPHATIDIC ACID (LPA) AND AUTOTAXIN
ASSAYS 709
Yutaka Yatomi, Koji Igarashi, Kazuhiro Nakamura, Ryunosuke Ohkawa, Akiko
Masuda, Akiko Suzuki, Tatsuya Kishimoto, Hitoshi Ikeda, and Junken Aoki
34 ANTIBODIES TO BIOACTIVE LYSOPHOSPHOLIPIDS 737
Roger A. Sabbadini, Jonathan M. Wojciak, Kelli Moreno, James S. Swaney, and
Barbara Visentin
INDEX 753
PREFACE ix
CONTRIBUTORS xi
1 LYSOPHOSPHATIDIC ACID (LPA) RECEPTOR SIGNALING 1
Hope Mirendil, Mu-En Lin, and Jerold Chun
2 SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTORS 41
Bongnam Jung and Timothy Hla
3 GLOBAL GENE EXPRESSION PROGRAM OF LYSOPHOSPHATIDIC ACID (LPA)-STIMULATED
FIBROBLASTS 61
Catelijne Stortelers and Wouter H. Moolenaar
4 IDENTIFICATION OF DIRECT INTRACELLULAR TARGETS OF SPHINGOSINE 1-PHOSPHATE
(S1P) 71
Nitai C. Hait, Sheldon Milstien, and Sarah Spiegel
5 LYSOPHOSPHOLIPID RECEPTOR SIGNALING PLATFORMS: THE RECEPTOR TYROSINE
KINASE-G PROTEIN-COUPLED RECEPTOR SIGNALING COMPLEX 85
Nigel J. Pyne and Susan Pyne
6 AUTOTAXIN: A UNIQUE ECTO-TYPE PYROPHOSPHODIESTERASE WITH DIVERSE
FUNCTIONS 103
Hiroshi Yukiura and Junken Aoki
7 STUDIES ON AUTOTAXIN SIGNALING IN ENDOCYTIC VESICLE BIOGENESIS AND
EMBRYONIC DEVELOPMENT USING WHOLE EMBRYO CULTURE AND ELECTROPORATION 121
Masayuki Masu, Seiichi Koike, Takuya Okada, and Kazuko Keino-Masu
8 STANDARDIZATION AND QUANTIFICATION OF LYSOPHOSPHATIDIC ACID COMPOUNDS BY
NORMAL-PHASE AND REVERSED-PHASE CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY 137
Jeff D. Moore, Shengrong Li, David S. Myers, Stephen B. Milne, H. Alex
Brown, and Walter A. Shaw
9 SPHINGOSINE KINASES: BIOCHEMISTRY, REGULATION, AND ROLES 153
Melissa R. Pitman, Kate E. Jarman, Tamara M. Leclercq, Duyen H. Pham, and
Stuart M. Pitson
10 FUNCTIONAL AND PHYSIOLOGICAL ROLES OF SPHINGOSINE 1-PHOSPHATE
TRANSPORTERS 185
Atsuo Kawahara and Tsuyoshi Nishi
11 LIPID PHOSPHATE PHOSPHATASES AND SIGNALING BY LYSOPHOSPHOLIPID RECEPTORS
201
Ganesh Venkatraman and David N. Brindley
12 LIPID PHOSPHATE PHOSPHATASES: RECENT PROGRESS AND ASSAY METHODS 229
Andrew J. Morris, Susan S. Smyth, Abdel K. Salous, and Andrew D. Renault
13 LYSOPHOSPHATIDIC ACID (LPA) SIGNALING AND CARDIOVASCULAR PATHOLOGY 265
Susan S. Smyth, Anping Dong, Jessica Wheeler, Manikandan Panchatcharam, and
Andrew J. Morris
14 SPHINGOSINE 1-PHOSPHATE (S1P) SIGNALING IN CARDIOVASCULAR PHYSIOLOGY AND
DISEASE 283
Bodo Levkau
15 SPHINGOSINE 1-PHOSPHATE (S1P) SIGNALING AND THE VASCULATURE 313
Christian Waeber
16 REGULATION OF THE NUCLEAR HORMONE RECEPTOR PPAR¿ BY ENDOGENOUS
LYSOPHOSPHATIDIC ACIDS (LPAS) 349
Ryoko Tsukahara, Tamotsu Tsukahara, and Gabor Tigyi
17 MECHANISMS AND MODELS FOR ELUCIDATING THE CARDIAC EFFECTS OF SPHINGOSINE
1-PHOSPHATE (S1P) 373
Shigeki Miyamoto, Sunny Yang Xiang, Nicole H. Purcell, and Joan Heller
Brown
18 NEURAL EFFECTS OF LYSOPHOSPHATIDIC ACID (LPA) SIGNALING 399
Nobuyuki Fukushima
19 WIDESPREAD EXPRESSION OF SPHINGOSINE KINASES AND SPHINGOSINE 1-PHOSPHATE
(S1P) LYASE SUGGESTS DIVERSE FUNCTIONS IN THE VERTEBRATE NERVOUS SYSTEM 419
H. Meng and V.M. Lee
20 LYSOPHOSPHATIDIC ACID AND NEUROPATHIC PAIN: DEMYELINATION AND LPA
BIOSYNTHESIS 433
Hiroshi Ueda
21 ROLE OF LYSOPHOSPHATIDIC ACID (LPA) IN BEHAVIORAL PROCESSES:
IMPLICATIONS FOR PSYCHIATRIC DISORDERS 451
Guillermo Estivill-Torrús, Luis Javier Santín, Carmen Pedraza, Estela
Castilla-Ortega, and Fernando Rodríguez de Fonseca
22 SPHINGOSINE 1-PHOSPHATE (S1P) SIGNALING AND LYMPHOCYTE EGRESS 475
Alejandra Mendoza, Lauren A. Pitt, and Susan R. Schwab
23 BIOLOGY REVEALED BY SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTOR GENE-ALTERED
MICE 489
Maria L. Allende, Mari Kono, Aikaterini Alexaki, Christina Giannouli, Jiman
Kang, Catherine C. Theisen, Eleanor L. Koerner, and Richard L. Proia
24 ROLE OF LYSOPHOSPHATIDIC ACID (LPA) IN THE INTESTINE 507
C. Chris Yun and Peijian He
25 LYSOPHOSPHOLIPID SIGNALING IN FEMALE AND MALE REPRODUCTIVE SYSTEMS 529
Xiaoqin Ye
26 THE GONADS AND THEIR MAGIC BULLET, LYSOPHOSPHATIDIC ACID: PHYSIOLOGICAL
AND TOXICOLOGICAL FUNCTIONS OF LYSOPHOSPHATIDIC ACID (LPA) IN FEMALE AND
MALE REPRODUCTIVE SYSTEMS 569
Lygia Therese Budnik, Bärbel Brunswig-Spickenheier, and Dieter Müller
27 LYSOPHOSPHOLIPID REGULATION OF LUNG FIBROSIS 587
Barry S. Shea and Andrew M. Tager
28 LYSOPHOSPHATIDIC ACID (LPA) SIGNALING AND BONE 609
Jean Pierre Salles, Sara Laurencin-Dalicieux, Françoise Conte-Auriol,
Fabienne Briand-Mésange, and Isabelle Gennero
29 LYSOPHOSPHATIDIC ACID (LPA) SIGNALING AND BONE CANCER 627
Olivier Peyruchaud, Marion David, Timothy L. Macdonald, and Kevin R. Lynch
30 UNDERSTANDING THE FUNCTIONS OF LYSOPHOSPHATIDIC ACID RECEPTORS IN CANCER
641
Nattapon Panupinthu and Gordon B. Mills
31 LYSOPHOSPHATIDIC ACID RECEPTORS IN CANCER 661
Abir Mukherjee, Jinhua Wu, Yongling Gong, and Xianjun Fang
32 LPA RECEPTOR SUBTYPES LPA1 AND LPA2 AS POTENTIAL DRUG TARGETS 681
Gretchen Bain and T. Jon Seiders
33 CLINICAL INTRODUCTION OF LYSOPHOSPHATIDIC ACID (LPA) AND AUTOTAXIN
ASSAYS 709
Yutaka Yatomi, Koji Igarashi, Kazuhiro Nakamura, Ryunosuke Ohkawa, Akiko
Masuda, Akiko Suzuki, Tatsuya Kishimoto, Hitoshi Ikeda, and Junken Aoki
34 ANTIBODIES TO BIOACTIVE LYSOPHOSPHOLIPIDS 737
Roger A. Sabbadini, Jonathan M. Wojciak, Kelli Moreno, James S. Swaney, and
Barbara Visentin
INDEX 753
CONTRIBUTORS xi
1 LYSOPHOSPHATIDIC ACID (LPA) RECEPTOR SIGNALING 1
Hope Mirendil, Mu-En Lin, and Jerold Chun
2 SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTORS 41
Bongnam Jung and Timothy Hla
3 GLOBAL GENE EXPRESSION PROGRAM OF LYSOPHOSPHATIDIC ACID (LPA)-STIMULATED
FIBROBLASTS 61
Catelijne Stortelers and Wouter H. Moolenaar
4 IDENTIFICATION OF DIRECT INTRACELLULAR TARGETS OF SPHINGOSINE 1-PHOSPHATE
(S1P) 71
Nitai C. Hait, Sheldon Milstien, and Sarah Spiegel
5 LYSOPHOSPHOLIPID RECEPTOR SIGNALING PLATFORMS: THE RECEPTOR TYROSINE
KINASE-G PROTEIN-COUPLED RECEPTOR SIGNALING COMPLEX 85
Nigel J. Pyne and Susan Pyne
6 AUTOTAXIN: A UNIQUE ECTO-TYPE PYROPHOSPHODIESTERASE WITH DIVERSE
FUNCTIONS 103
Hiroshi Yukiura and Junken Aoki
7 STUDIES ON AUTOTAXIN SIGNALING IN ENDOCYTIC VESICLE BIOGENESIS AND
EMBRYONIC DEVELOPMENT USING WHOLE EMBRYO CULTURE AND ELECTROPORATION 121
Masayuki Masu, Seiichi Koike, Takuya Okada, and Kazuko Keino-Masu
8 STANDARDIZATION AND QUANTIFICATION OF LYSOPHOSPHATIDIC ACID COMPOUNDS BY
NORMAL-PHASE AND REVERSED-PHASE CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY 137
Jeff D. Moore, Shengrong Li, David S. Myers, Stephen B. Milne, H. Alex
Brown, and Walter A. Shaw
9 SPHINGOSINE KINASES: BIOCHEMISTRY, REGULATION, AND ROLES 153
Melissa R. Pitman, Kate E. Jarman, Tamara M. Leclercq, Duyen H. Pham, and
Stuart M. Pitson
10 FUNCTIONAL AND PHYSIOLOGICAL ROLES OF SPHINGOSINE 1-PHOSPHATE
TRANSPORTERS 185
Atsuo Kawahara and Tsuyoshi Nishi
11 LIPID PHOSPHATE PHOSPHATASES AND SIGNALING BY LYSOPHOSPHOLIPID RECEPTORS
201
Ganesh Venkatraman and David N. Brindley
12 LIPID PHOSPHATE PHOSPHATASES: RECENT PROGRESS AND ASSAY METHODS 229
Andrew J. Morris, Susan S. Smyth, Abdel K. Salous, and Andrew D. Renault
13 LYSOPHOSPHATIDIC ACID (LPA) SIGNALING AND CARDIOVASCULAR PATHOLOGY 265
Susan S. Smyth, Anping Dong, Jessica Wheeler, Manikandan Panchatcharam, and
Andrew J. Morris
14 SPHINGOSINE 1-PHOSPHATE (S1P) SIGNALING IN CARDIOVASCULAR PHYSIOLOGY AND
DISEASE 283
Bodo Levkau
15 SPHINGOSINE 1-PHOSPHATE (S1P) SIGNALING AND THE VASCULATURE 313
Christian Waeber
16 REGULATION OF THE NUCLEAR HORMONE RECEPTOR PPAR¿ BY ENDOGENOUS
LYSOPHOSPHATIDIC ACIDS (LPAS) 349
Ryoko Tsukahara, Tamotsu Tsukahara, and Gabor Tigyi
17 MECHANISMS AND MODELS FOR ELUCIDATING THE CARDIAC EFFECTS OF SPHINGOSINE
1-PHOSPHATE (S1P) 373
Shigeki Miyamoto, Sunny Yang Xiang, Nicole H. Purcell, and Joan Heller
Brown
18 NEURAL EFFECTS OF LYSOPHOSPHATIDIC ACID (LPA) SIGNALING 399
Nobuyuki Fukushima
19 WIDESPREAD EXPRESSION OF SPHINGOSINE KINASES AND SPHINGOSINE 1-PHOSPHATE
(S1P) LYASE SUGGESTS DIVERSE FUNCTIONS IN THE VERTEBRATE NERVOUS SYSTEM 419
H. Meng and V.M. Lee
20 LYSOPHOSPHATIDIC ACID AND NEUROPATHIC PAIN: DEMYELINATION AND LPA
BIOSYNTHESIS 433
Hiroshi Ueda
21 ROLE OF LYSOPHOSPHATIDIC ACID (LPA) IN BEHAVIORAL PROCESSES:
IMPLICATIONS FOR PSYCHIATRIC DISORDERS 451
Guillermo Estivill-Torrús, Luis Javier Santín, Carmen Pedraza, Estela
Castilla-Ortega, and Fernando Rodríguez de Fonseca
22 SPHINGOSINE 1-PHOSPHATE (S1P) SIGNALING AND LYMPHOCYTE EGRESS 475
Alejandra Mendoza, Lauren A. Pitt, and Susan R. Schwab
23 BIOLOGY REVEALED BY SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTOR GENE-ALTERED
MICE 489
Maria L. Allende, Mari Kono, Aikaterini Alexaki, Christina Giannouli, Jiman
Kang, Catherine C. Theisen, Eleanor L. Koerner, and Richard L. Proia
24 ROLE OF LYSOPHOSPHATIDIC ACID (LPA) IN THE INTESTINE 507
C. Chris Yun and Peijian He
25 LYSOPHOSPHOLIPID SIGNALING IN FEMALE AND MALE REPRODUCTIVE SYSTEMS 529
Xiaoqin Ye
26 THE GONADS AND THEIR MAGIC BULLET, LYSOPHOSPHATIDIC ACID: PHYSIOLOGICAL
AND TOXICOLOGICAL FUNCTIONS OF LYSOPHOSPHATIDIC ACID (LPA) IN FEMALE AND
MALE REPRODUCTIVE SYSTEMS 569
Lygia Therese Budnik, Bärbel Brunswig-Spickenheier, and Dieter Müller
27 LYSOPHOSPHOLIPID REGULATION OF LUNG FIBROSIS 587
Barry S. Shea and Andrew M. Tager
28 LYSOPHOSPHATIDIC ACID (LPA) SIGNALING AND BONE 609
Jean Pierre Salles, Sara Laurencin-Dalicieux, Françoise Conte-Auriol,
Fabienne Briand-Mésange, and Isabelle Gennero
29 LYSOPHOSPHATIDIC ACID (LPA) SIGNALING AND BONE CANCER 627
Olivier Peyruchaud, Marion David, Timothy L. Macdonald, and Kevin R. Lynch
30 UNDERSTANDING THE FUNCTIONS OF LYSOPHOSPHATIDIC ACID RECEPTORS IN CANCER
641
Nattapon Panupinthu and Gordon B. Mills
31 LYSOPHOSPHATIDIC ACID RECEPTORS IN CANCER 661
Abir Mukherjee, Jinhua Wu, Yongling Gong, and Xianjun Fang
32 LPA RECEPTOR SUBTYPES LPA1 AND LPA2 AS POTENTIAL DRUG TARGETS 681
Gretchen Bain and T. Jon Seiders
33 CLINICAL INTRODUCTION OF LYSOPHOSPHATIDIC ACID (LPA) AND AUTOTAXIN
ASSAYS 709
Yutaka Yatomi, Koji Igarashi, Kazuhiro Nakamura, Ryunosuke Ohkawa, Akiko
Masuda, Akiko Suzuki, Tatsuya Kishimoto, Hitoshi Ikeda, and Junken Aoki
34 ANTIBODIES TO BIOACTIVE LYSOPHOSPHOLIPIDS 737
Roger A. Sabbadini, Jonathan M. Wojciak, Kelli Moreno, James S. Swaney, and
Barbara Visentin
INDEX 753