Laurent Simon, Juan Ospina

Closed-Form Solutions for Drug Transport Through Controlled-Release Devices in Two and Three Dimensions

• Gebundenes Buch

Produktbeschreibung

Provides solutions for two- and three-dimensional linear models of controlled-release systems Designed to administer an exact dosage of an API to a target site during a treatment period, controlled-release drug-delivery systems regulate the therapeutic agent release rate while it is being delivered to a particular location Closed-form Solutions for Drug Transport through Controlled-Release Devices in Two and Three Dimensions covers various classical and analytical techniques to solve boundary-value problems involving two- and three-dimensional partial differential equations (PDEs.) These methods are applied to study drug-transport mechanisms in 2-D and 3-D coordinate systems and result in a detailed picture of the evolution of active pharmaceutical ingredients (APIs) through a controlled-released (CR) device or a membrane. Mathematical modeling platforms, that can represent the transport mechanisms adequately, are important assets in the fabrication of these products, as well. This book shows how analytical tools, routinely used by physicists, mathematicians and engineers, can be implemented to guide the design of CR devices. A host of diverse real-world applications are taken from the literature to help illustrate the methods in Cartesian, cylindrical and spherical coordinate systems. Closed-form Solutions for Drug Transport through Controlled-Release Devices in Two and Three Dimensions features: * Real-world applications are taken from used to help illustrate the methods in Cartesian, cylindrical and spherical coordinate systems * Modeling of drug-delivery systems and provide mathematical tools to evaluate and build controlled-release devices * Classical and analytical techniques to solve boundary-value problems involving two- and three-dimensional partial differential equations * Detailed examples, case studies and step-by-step analytical solutions to relevant problems using popular computational software The textbook is presented in a manner to help the reader apply the theory to their problems. For researchers in the field, the integration of modeling and simulations at an early design stage is crucial in the development of new technologies. The materials covered in the book will help provide a good foundation for anyone who wishes to be involved in cutting-edge drug-delivery research. Laurent Simon, PhD, is Associate Professor of Chemical Engineering and served as the Associate Director of the Pharmaceutical Engineering Program at New Jersey Institute of Technology. Dr. Simon is the author of Laboratory Online, a series of educational and interactive modules that help engineers build a strong understanding of drug delivery technologies and their underlying engineering principles. During his time at NJIT, Dr. Simon has received the Excellence in Teaching Award, Master Teacher Designation, Newark College of Engineering Saul K. Fenster Innovation in Engineering Education Award and a Distinguished Teaching Award from the American Society of Engineering Education (ASEE). Juan Ospina is currently an Assistant Professor at EAFIT University in the Logic and Computation Group, Physics Engineering Program. He has published numerous article on the topic of mathematical physics.

---

Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.

Produktdetails

• Verlag: Wiley
• Seitenzahl: 304
• Erscheinungstermin: 27. April 2015
• Englisch
• Abmessung: 236mm x 152mm x 20mm
• Gewicht: 567g
• ISBN-13: 9781118947258
• ISBN-10: 1118947258
• Artikelnr.: 42282873

Autorenporträt

Laurent Simon, PhD, is Associate Professor of Chemical Engineering and served as the Associate Director of the Pharmaceutical Engineering Program at New Jersey Institute of Technology. Dr. Simon is the author of Laboratory Online, a series of educational and interactive modules that help engineers build a strong understanding of drug delivery technologies and their underlying engineering principles. During his time at NJIT, Dr. Simon has received the Excellence in Teaching Award, Master Teacher Designation, Newark College of Engineering Saul K. Fenster Innovation in Engineering Education Award and a Distinguished Teaching Award from the American Society of Engineering Education (ASEE). Juan Ospina is currently an Assistant Professor at EAFIT University in the Logic and Computation Group, Physics Engineering Program. He has published numerous articles on the topic of mathematical physics.

Inhaltsangabe

Preface ix
Acknowledgements xi
1 Steady-State Analysis of a Two-Dimensional Model for Percutaneous Drug
Transport 1
1.1 Separation of Variables in 2-D Cartesian Coordinates1
1.2 Model for Drug Transport across the Skin 3
1.3 Analytical Solution of the Diffusion Model in 2-D Cartesian Systems 4
1.4 Summary 6
1.5 Appendix: Maple, Mathematica, and Maxima Code Listings 6
Problems 10
References 12
2 Constant Drug Release from a Hollow Cylinder of Finite Length in Two
Dimensions 13
2.1 Separation of Variables in 2-D Cylindrical Coordinates 13
2.2 Model for Drug Release from a Hollow Cylinder 15
2.3 Analytical Solution of the Transport Model in 2-D Cylindrical
Coordinates 15
2.4 Summary 19
2.5 Appendix: Maple Code Listings 19
Problems 20
References 20
3 Analysis of Steady-State Growth Factor Transport Through Double-Layered
Scaffolds 23
3.1 Governing Steady-State Transport Equations 23
3.2 Solution Procedure for Transport Through a Two-Layered Scaffold 25
3.3 Concentration Profile of Vascular Endothelial Growth Factor in Two
Layers 31
3.4 Summary 32
3.5 Appendix: Maple Code Listings 33
Problems 37
References 38
4 Steady-State Two-Dimensional Diffusion in a Hollow Sphere 39
4.1 Separation of Variables and Legendre Polynomials in 2-D Spherical
Coordinates 39
4.2 Model For 2-D Diffusion in a Sphere 43
4.3 Analytical Solution of 2-D Diffusion in Spherical Coordinates 46
4.4 Summary 49
4.5 Appendix: Maple, Mathematica, and Maxima Code Listings 49
Problems 56
References 57
5 Steady-State Three-Dimensional Drug Diffusion through Membranes from
Distributed Sources 59
5.1 Separation of Variables in 3-D Cartesian Coordinates 59
5.2 Transport across the Membrane 61
5.3 Analytical Solution of the Diffusion Model in 3-D Cartesian Systems 63
5.4 Summary 68
5.5 Appendix: Maple Code Listings 69
Problems 73
References 73
6 Constant Drug Release from a Hollow Cylinder of Finite Length in Three
Dimensions 75
6.1 Separation of Variables in 3-D Cylindrical Coordinates 75
6.2 Model For 3-D Drug Release from a Hollow Cylinder 77
6.3 Analytical Solution of the Transport Model in 3-D Cylindrical
Coordinates 78
6.4 Summary 84
6.5 Appendix: Maple Code Listings 85
Problems 87
References 87
7 Sustained Drug Release from a Hollow Sphere in Three Dimensions 89
7.1 Method of Green's Function in 3-D Spherical Coordinates 89
7.2 Model for Molecular Transport across the Wall of a Hollow Sphere 95
7.3 Analytical Solution of the Transport Model in 3-D Spherical Coordinates
96
7.4 Summary 97
7.5 Appendix: Maple, Mathematica and Maxima Code Listings 98
Problems 105
References 105
8 Analysis of Transient Growth Factor Transport Through Double-Layered
Scaffolds 107
8.1 Laplace and Fourier-Bessel-based Methods in 2-D Cylindrical Coordinates
107
8.2 Governing Equations for Transport through Double-Layered Scaffolds 112
8.3 Concentration Profile of Vascular Endothelial Growth Factor in Two
Layers 114
8.4 Summary 119
8.5 Appendix: Maple Code Listings 120
Problems 126
References 126
9 Molecular Diffusion through the Stomach Lining and into the Bloodstream
129
9.1 Laplace Transforms, Legendre Functions and Spherical Harmonics129
9.2 Spherical Diffusion in Three Dimensions 132
9.3 Analytical Solution of the Transient Transport Model in 3-D Spherical
Coordinates 133
9.4 Summary 138
9.5 Appendix: Maple Code Listings 138
Problems 141
References 143
10 Diffusion-Controlled Ligand Binding to Receptors on Cell Surfaces 145
10.1 Weber's Integral 145
10.2 Steady-State Diffusion-Limited Ligand Binding 148
10.3 Transient Diffusion-Controlled Ligand Binding in 2-D Cylindrical
Coordinates 151
10.4 Summary 156
10.5 Appendix: Maple, Mathematica and Maxima Code Listings 156
Problems 167
References 168
11 Two-Dimensional Analysis of a Cylindrical Matrix Device with a Small
Hole For Drug Release 169
11.1 Mathematical Modeling of Drug Transport through the Device 169
11.2 Drug Concentration Profile inside the Matrix 171
11.3 Normalized Cumulative Percentage of Drug Released 177
11.4 Summary 178
11.5 Appendix: Maple Code Listings 178
Problems 182
References 183
12 Three-Dimensional Drug Diffusion through Membranes from Distributed
Sources 185
12.1 Governing Equations of the Transport Model 185
12.2 Analytical Solution of the Diffusion Model in 3-D Cartesian Systems
187
12.3 Average Dimensionless Concentration and Flux 194
12.4 Summary 194
12.5 Appendix: Maple and Mathematica Code Listings 195
Problems 207
References 207
13 Effective Time Constant for Two- and Three-Dimensional
Controlled-Released Drug-Delivery Models 209
13.1 Effective Time Constant in Controlled-Release Drug-Delivery Systems
209
13.2 Intravitreal Drug Delivery using a 2-D Cylindrical Model 210
13.3 Analysis of a Rectangular Parallelepiped-Shaped Matrix with a Release
Area 218
13.4 Summary 225
13.5 Appendix: Maple and Mathematica Code Listings 225
Problems 232
References 232
14 Data Fitting For Two- and Three-Dimensional Controlled- Release
Drug-Delivery Models 233
14.1 Data Fitting in Controlled-Release Drug-Delivery Systems 233
14.2 Estimation of Diffusion Coefficient in a Solid Cylinder of Finite
Length 234
14.3 Estimation of Diffusion Coefficient in a Rectangular
Parallelepiped-Shaped Matrix 240
14.4 Summary 243
14.5 Appendix: Maple and Mathematica Code Listings 244
Problems 256
References 258
15 Optimization of Two- and Three-Dimensional Controlled-Released
Drug-Delivery Models 259
15.1 Optimum Design of Controlled-Released Drug-Delivery Systems 259
15.2 Design of a 2-D Cylindrical Dosage Form with a Finite Mass Transfer
Coefficient 260
15.3 Design of a Rectangular Parallelepiped-Shaped Matrix with a Finite
Mass Transfer Coefficient 265
15.4 Summary 268
15.5 Appendix: Maple and Mathematica Code Listings 268
Problems 282
References 283
Index 285