The effects of erythropoietin on telomerase in malignant cells - Uziel, Orit;Kanfer, Gil;Lahav, Meir
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The study described in this book presents the effects of erythropoietin on Telomerase activity and regulation in malignant and non- malignant non-erythroid cells. Erythropoietin's exposure upregulates telomerase activity in a post translational level by the Lyn/SRC AKT axis. Inhibition of telomerase that shortens telomeres abolished that effect, suggesting that erythropoietin's treatment might be given with anti- telomerase compounds to minimize the upregulation of telomerase in the cancer cells.

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Produktbeschreibung
The study described in this book presents the effects of erythropoietin on Telomerase activity and regulation in malignant and non- malignant non-erythroid cells. Erythropoietin's exposure upregulates telomerase activity in a post translational level by the Lyn/SRC AKT axis. Inhibition of telomerase that shortens telomeres abolished that effect, suggesting that erythropoietin's treatment might be given with anti- telomerase compounds to minimize the upregulation of telomerase in the cancer cells.
Autorenporträt
Orit Uziel got her Ph.D degree from the Tel Aviv University, Israel at 2000. Since then she is running the Laboratory for Telomere Research together with prof. Lahav and Prof. Nordenberg at the Felsenstein Medical Research Center, Rabin Medical Center and Tel Aviv University. The main focus of her laboratory is translational research.