Rheumatoid arthritis is a chronic progressive autoimmune disorder characterized by symmetric erosive synovitis and also shows multisystem involvements. Reactive oxygen species are clearly involved in the pathogenesis of RA. This book shows the significant rise in serum ferritin is highly associated with higher oxidative stress in RA patients as compared to the normal healthy controls. Serum ferritin acts as an acute phase reactant and its rise is due to inflammatory response to the rising oxidative stress in Rheumatoid Arthritis.