Characterization of dihydroorotate dehydrogenase for malaria therapy - Kago, Leah;Caing-Carlsson, Rhawnie;Friemann, Rosmarie
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Malaria remains a world's disease burden causing high incidences of mortality in susceptible populations.Severe cases of malaria are caused by parasites of the apicomplexan Plasmodium falciparum localized in sub-saharan Africa whereas less severe malaria but most prevalent outside Africa is caused by Plasmodium vivax.Malaria campaigns through vector control and effective artemesinins-based combination therapy has considerably reduced malarial mortality ratesin the past decade.However, increasing cases of drug resistance has raised an urgent need for development of new anti-malarial drugs.…mehr

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Produktbeschreibung
Malaria remains a world's disease burden causing high incidences of mortality in susceptible populations.Severe cases of malaria are caused by parasites of the apicomplexan Plasmodium falciparum localized in sub-saharan Africa whereas less severe malaria but most prevalent outside Africa is caused by Plasmodium vivax.Malaria campaigns through vector control and effective artemesinins-based combination therapy has considerably reduced malarial mortality ratesin the past decade.However, increasing cases of drug resistance has raised an urgent need for development of new anti-malarial drugs. In-silico drug design using the structure of the biological target is the latest lead optimization option in search of more potent drugs.In this work, i sought to determine the 3-dimensional structure of the biological target,dehydroorotate dihydrogenase(DHODH) from the above mentioned plasmodia species co-crystallized with novel drug candidates.Characterization of the parasitic DHODH involved target gene cloning,site directed mutagenesis,protein expression and purification and subsequent co-crystallization for structure determination.This book therefore,targets life science research professionals
Autorenporträt
Leah W. Kago; Studied BSc chemistry/biochemistry at University of Nairobi,2006 in Kenya and MSc biotechnology at Chalmers University of Technology,2012 in Sweden.My past employment was in the floriculture industry as a microbiologist at Dudutech (k) ltd and currrently seeking for a job in the scientific research field.