A series of new 2-(1-(aminomethyl)cyclohexyl)acetic acid derivatives, 4a-j was synthesized and their biological activity was determined. The chemical structures were confirmed by elemental analyses, UV-visible, FT-IR and 1H NMR spectral studies. The structure-activity relationship for antioxidant activity was discussed. Most of the new compounds showed DPPH radical scavenging activity, where compounds 4f, 4d and 4e were the best radical scavengers.