Linda Valmorri

My Clinical Research Activities 2008-2010

Focus On The Role Of Anti-ctla-4 Therapy In The Treatment Of Advanced Melanoma

• Broschiertes Buch

Produktbeschreibung

This book describes my recent clinical research activities. The first work Glutatione-S-Transferase (GSTP1): a Plasma Molecular Marker to Define the Risk of Prostate Cancer is a prospectively planned case-control study to evaluate the performance of the GSTP1 promoter methylation assay in blood samples as a new diagnostic marker to improve the early diagnosis of prostate cancer. The combined analysis of PSA levels, age and GSTP1 hypermethylation could improve prostate cancer diagnosis. The second project MGMT promoter methylation status and Poly (ADP-Ribose) Polymerase (PARP)-1 expression in Advanced Melanoma aims to assess MGMT promoter methylation and PARP-1 expression status in the tissue samples of advanced melanoma patients. PARP-1 appears to increase melanoma chemosensitivity and shows potential as a new therapeutic strategy. The last part of the book is dedicated to my activity of clinical trials coordinator; the report on 36 heavily pretreated metastatic patients treated at my Institution (IRCCS IRST, Meldola) with Ipilimumab in 4 international clinical trials and a compassionate use program describes unusually long-lasting responses evaluated according to novel irRC.

Produktdetails

• Verlag: LAP Lambert Academic Publishing
• Seitenzahl: 128
• Erscheinungstermin: 13. Oktober 2012
• Englisch
• Abmessung: 220mm x 150mm x 8mm
• Gewicht: 209g
• ISBN-13: 9783659274695
• ISBN-10: 3659274690
• Artikelnr.: 36648930

Autorenporträt

Degree in Biotechnology (2002) and in Molecular and Cellular Biology (2009). Specialization School in Clinical Biochemistry (2007) and PhD in Clinical and Experimental Medicine (2011).I worked at various research laboratories of Cytogenetics and Molecular Biology and now I am a DataManager and Study Coordinator at IRCCS IRST of Meldola (Italy).