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Nanoparticles were greatly acceptable and continuously studied on wide range of application. Both toxicity and water-solubility are main requirements to conducting nanoparticles on biomedical field. For several cases, the excellence features offered by nanoparticles remained problems related to complicating way on preparing water-soluble nanoparticles and how make them be an efficient and effective probe. This book highlights on transferring methods of oil-soluble nanoparticles with regarded on performing colloidal stability of nanoparticles. The authors deal on using non-covalent approach on each strategy to promotes a facile as well as simple process within minimize degradation the original properties of transferred nanoparticles. Starting on utilizing some of small molecules as transferring agent, this book further observes the chance of macromolecules on the process. The works shown here is the result over two years research after rejecting some unrelated parts. The exploration on optimizing the inherent properties, drug delivery, and multi-tasking capability of nanoparticles on cancer treatments are also demonstrated, even so committed on facile phase transfer strategies.