Machine Learning (ML), a field of artificial intelligence, is concerned with the design and development of new algorithms that allow computers to learn behaviors based on observed data. Genetic Folding as a novel algorithm inspired by RNA and DNA folding, GF algorithm thereby offering a simple and inexpensive way of studying problems without a need of implementing complexity models. Genetic Folding: New Computational Intelligence Models book is introduced with wide range of experiments the ability of GF as a new AI algorithm. In addition to GF algorithm, the book introduces a novel method named as Alignment Algorithm.