This book presents a beneficial reference to those who are interested in study Cloud Computing and Grid. It introduces a guide for installing and configuring Cloud and Grid infrastructure which used Hadoop framework for Cloud and Globus for Grid. Also it designed to brief a comparison between Cloud and Grid in terms of Data transmission performance. In additional, it proposes a new framework called Grid-over-Hadoop by retaining the features of Hadoop and using GridFTP for data analyze and data transfer for Hadoop, which give the reader a clear view about integrating two environments using an effective middleware.