NAFLD has become the most prevalent cause of liver disease worldwide, and the development of NASH and fibrosis identifies the risk group with increase incidence of liver-related deaths. Fifty four obese patients with suspected fatty liver by abdominal ultrasound were subjected to full history taking and physical examination, full anthropometric measurements, laboratory studies including serum adiponectin and resistin, abdominal US, and sonar-guided liver biopsy "for pathological examination and measuring adiponetin and resistin gene expression". Also fifteen age-matched healthy non-obese subjects were included as a control group for serum adiponectin & resistin. According to the results of biopsy, patients were subdivided into NASH group patients) and non-NASH group, and the 2 groups were compared as regards different parameters. This book investigates adiponectin and resistin as non-invasive predictors of NAFLD.