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1. Depression, noun Feelings of severe despondency and dejection. "self-doubt creeps in and that swiftly turns to depression" Synonyms: melancholy. misery, sadness, unhappiness, sorrow, woe, gloom, gloominess, dejection, downheartedness, despondency, dispiritedness, low spirits, heavy-heartedness, moroseness, discouragement, despair, desolation, dolefulness, moodiness, pessimism, hopelessness There is no shame in getting help. If you or a loved one are even considering self-harm, please reach out: National Suicide Prevention Lifeline 1-800-273-8255