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Nitric oxide (NO) has been found to play many diverse physiological roles, ranging from a neurotransmitter to an active participant in wound healing. In the present work, we have developed several polymeric devices using the electrospinning technique for the sustained, site specific delivery of nitric oxide. In addition to a multilayered patch, a topical cream was developed. The cream can be applied topically for the site specific delivery of NO. The results show stable, sustained and site specific delivery of NO.