In this book, simulation of different Antenna shapes such as Rectangular, E-shape, Psi-shape Micro-strip Antenna (MSA) is shown by studying various Micro-strip configuration & Mathematical design using High Frequency Structure Simulator (HFSS) software. The performance of single layer Rectangular MSA has been measured for different dielectric substrate materials. For FR-4 epoxy material cost is low where as improve in Bandwidth is achieved. Simulation is done for conventional single Layer and Multi-layer Rectangular, E-shape, Psi-shape. It is observed that Multi-layer shapes has improved behavior over conventional single Layer MSA in terms of parameters like Return Loss Bandwidth, Gain, VSWR, Directivity and Radiation Pattern.