Brenda A. Wilson, Malcolm Winkler, Brian T. Ho

Bacterial Pathogenesis (eBook, ePUB)

A Molecular Approach

• Format: ePub

Produktbeschreibung

This highly anticipated update of the acclaimed textbook draws on the latest research to give students the knowledge and tools to explore the mechanisms by which bacterial pathogens cause infections in humans and animals. Written in an approachable and engaging style, the book uses illustrative examples and thought-provoking exercises to inspire students with the potential excitement and fun of scientific discovery.

Completely revised and updated, and for the first time in stunning full-color, Bacterial Pathogenesis: A Molecular Approach, Fourth Edition, builds on the core principles and foundations of its predecessors while expanding into new concepts, key findings, and cutting-edge research, including new developments in the areas of the microbiome and CRISPR as well as the growing challenges of antimicrobial resistance. All-new detailed illustrations help students clearly understand important concepts and mechanisms of the complex interplay between bacterial pathogens and their hosts. Study questions at the end of each chapter challenge students to delve more deeply into the topics covered, and hone their skills in reading, interpreting, and analyzing data, as well as devising their own experiments. A detailed glossary defines and expands on key terms highlighted throughout the book. Written for advanced undergraduate, graduate, and professional students in microbiology, bacteriology, and pathogenesis, this text is a must-have for anyone looking for a greater understanding of virulence mechanisms across the breadth of bacterial pathogens.

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Produktdetails

• Verlag: John Wiley & Sons
• Erscheinungstermin: 1. Juli 2019
• Englisch
• ISBN-13: 9781683672883
• Artikelnr.: 72556087

Autorenporträt

Brenda A. Wilson, Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana-Champaign, Illinois.

Malcolm E. Winkler, Department of Biology, Indiana University, Bloomington, Indiana.

Brian T. Ho, Institute of Structural and Molecular Biology, University College London and Birkbeck, University of London, London, United Kingdom.

Inhaltsangabe

Preface xvii

In Memoriam xix

About the Authors xxi

Chapter 1 The Power of Bacteria 2

Why Are Bacteria So Much in the Public Health Spotlight Nowadays? 3

Bacteria, a Formidable Ancient Life Form 4

Pressing Current Infectious Disease Issues 6

Emerging and Reemerging Infectious Diseases 6

Foodborne and Waterborne Infections 7

Modern Medicine as a Source of New Diseases 8

Postsurgical and Other Wound Infections 9

Bioterrorism 10

A New Respect for Prevention 10

Surveillance: An Early Warning System 11

Making Hospitals Safe for Patients 12

And Now for Some Good News: You've Got a Bacterial Infection! 12

The Helicobacter pylori Revolution 12

The Aftermath 13

Microbiota Shift Diseases 13

A Brave New World of Pathogenesis Research 14

The New Age of Genomics 16

Insights into Pathogen Evolution 17

Modeling the Host-Pathogen Interaction in Experimental Animals 17

Correlation Studies 18

Selected Readings 18

Questions 20

Chapter 2 Skin and Mucosa: The First Lines of Defense against Bacterial Infections 22

The Best Defense: Avoid, Reduce, and Prevent Exposure! 23

Barriers: Skin and Mucosal Membranes 24

The Layers of Cells That Protect the Body 24

Normal Microbiota of the Skin and Mucosa 27

Defenses of the Skin 31

Defenses of Mucosal Surfaces 32

Special Defenses of the Gastrointestinal Tract 34

Special Defenses of the Urogenital Tract 36

Special Defenses of the Respiratory Tract 36

Immune Defenses of the Skin and Mucosa 37

Models for Studying Breaches of Barrier Defenses 38

Selected Readings 39

Questions 39

Chapter 3 The Innate Immune System: Always on Guard 40

Triggering Innate Immune Defenses 41

Innate Immune Cells That Defend Blood and Tissue 42

Neutrophils (PMNs) 42

Monocytes, Macrophages, and Dendritic Cells (DCs) 42

Granulocytes: Basophils, Mast Cells, and Eosinophils 47

Transmigration--How Do Phagocytes Know When and Where to Go? 47

Natural Killer (NK) Cells 48

The Lymphatic System 50

How Phagocytes Recognize and Respond to Bacteria 50

How Phagocytes Kill Bacteria 54

Oxidative Burst in Phagolysosomes 54

Autophagy--Another Pathway for the Killing of Intracellular Pathogens 56

The Complement Cascade 57

Complement Proteins 57

Overview of Complement Pathways and Their Function 58

Steps in Complement Activation 60

Controlling Complement Activation 62

Cytokines and Chemokines--Mediators of Immune Responses 63

Roles of Cytokines and Chemokines in Directing Innate Immune Responses 63

Inflammation and Collateral Damage 65

Septic Shock: The Dark Side of the Innate Defenses 66

Other Innate Defenses of the Body--Nutritional Immunity 69

Selected Readings 70

Questions 70

Chapter 4 The Adaptive Defenses: Antibodies and Cytotoxic T Cells 72

The Specialists: Adapting to a Particular Pathogen Challenge 73

B Cells: Producers of Antibodies 74

The Humoral (Antibody) Immune Response 74

Characteristics of Antibodies and Their Diverse Roles in Preventing Infection 74

Serum Antibodies 76

Secretory Antibodies: Antibodies That Protect Mucosal Surfaces 78

Pathogen and Toxin Neutralization by Antibodies 79

Affinity and Avidity 80