Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. The acclaimed practice-oriented introduction to physical pharmacy Emphasizing relevancy to practice, clarity of presentation, and utilizing practice-oriented examples and case studies, this acclaimed text is the ideal learning tool for pharmacy students as well as practitioners who want to sharpen their pharmaceutical skills. With numerous examples from the pharmacy practice, this textbook presents the…mehr
Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. The acclaimed practice-oriented introduction to physical pharmacy Emphasizing relevancy to practice, clarity of presentation, and utilizing practice-oriented examples and case studies, this acclaimed text is the ideal learning tool for pharmacy students as well as practitioners who want to sharpen their pharmaceutical skills. With numerous examples from the pharmacy practice, this textbook presents the chemical and physical principles fundamental to the development of medication dosage forms. Numerous case studies present relevant examples of physical and chemical principles in current pharmacy practice.Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
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Inhaltsangabe
Contributors Preface 1. Introduction to Biopharmaceutics Introduction Drug Disposition-The Fate of the Drug After Administration Ladme Conclusion Key Point Clinical Questions 2. States of Matter Related to Pharmaceutical Formulations Introduction Intermolecular Forces States of Matter Stability of Solids Acknowledgment Problems Answers Key Points Clinical Questions Appendix 3. Physical Properties of Solutions General Considerations Concentration Expressions Classification of Aqueous Solution Systems Physical Properties of Solutions Physiologic Applications of Colligative Properties Isotonic Solutions Sodium Chloride Equivalent Values (E) Problems Answers Key Points Clinical Questions Appendix 4. Ionic Equilibria and Buffers Electrolytes Versus Nonelectrolytes Importance of Ionization in Pharmacy Acids and Bases Ionization of Water Ionization of Electrolytes Ionization of Salts Buffers Ionization of Amphoteric Electrolytes Ionization of Polyprotic Acids Activity and Activity Coefficient Acid-Base Titration and Titration Curve Problems Answers Key Points Clinical Questions Appendix Suggested Readings 5. Solubility, Dissolution, and Partitioning Solubility Dissolution Dissolution of Particles Factors Affecting Drug Dissolution Partitioning Solubility Problems Answers Dissolution Problems Answers Partitioning Problems Answers Key Points Clinical Questions Appendix 6. Mass Transport Introduction Transport Systems Diffusion Through a Membrane Significance of Diffusion Significance of Osmosis Problems Answers Key Points Clinical Questions 7. Complexation and Protein Binding Introduction Types of Complexes Metal-Ion Coordinate Complexes Cyclodextrin Complexes Ion-Exchange Resins Protein-Ligand Interactions Plasma Protein Binding Problems Answers Key Points Clinical Questions Appendix 8. Dispersed Systems Dispersed Systems Classified by Their Phases Dispersed Systems Classified by Their Particle Size Physical Stability of Dispersed Systems Summary Problems Answers Key Points Clinical Questions Suggested Readings 9. Interfacial Phenomena Surface Tension Electrical Double Layer Adsorption Problems Answers Key Points Clinical Questions Appendix 10. Rheology Introduction Newtonian Flow Viscosity of Newtonian Fluids Effect of Temperature on Viscosity Non-Newtonian Flow Thixotropy Viscoelasticity Significance of Rheology Viscosity Modifiers Problems Answers Key Points Clinical Questions Appendix 11. Chemical Kinetics of Pharmaceuticals Common Drug Degradation Reactions Order of Reaction Determination of the Order of a Reaction Stability and Shelf-Life of Drugs Enzyme Catalysis Reactions Pharmacokinetics: An Extension of Reaction Kinetics Problems Answers Clinical Questions Suggested Readings Appendix: Basic Mathematical Concepts Equations Logarithmic Function Exponential Function Differentiation and Integration Functions Bibliography Mathematical Tables Endnotes Index
Contributors Preface 1. Introduction to Biopharmaceutics Introduction Drug Disposition-The Fate of the Drug After Administration Ladme Conclusion Key Point Clinical Questions 2. States of Matter Related to Pharmaceutical Formulations Introduction Intermolecular Forces States of Matter Stability of Solids Acknowledgment Problems Answers Key Points Clinical Questions Appendix 3. Physical Properties of Solutions General Considerations Concentration Expressions Classification of Aqueous Solution Systems Physical Properties of Solutions Physiologic Applications of Colligative Properties Isotonic Solutions Sodium Chloride Equivalent Values (E) Problems Answers Key Points Clinical Questions Appendix 4. Ionic Equilibria and Buffers Electrolytes Versus Nonelectrolytes Importance of Ionization in Pharmacy Acids and Bases Ionization of Water Ionization of Electrolytes Ionization of Salts Buffers Ionization of Amphoteric Electrolytes Ionization of Polyprotic Acids Activity and Activity Coefficient Acid-Base Titration and Titration Curve Problems Answers Key Points Clinical Questions Appendix Suggested Readings 5. Solubility, Dissolution, and Partitioning Solubility Dissolution Dissolution of Particles Factors Affecting Drug Dissolution Partitioning Solubility Problems Answers Dissolution Problems Answers Partitioning Problems Answers Key Points Clinical Questions Appendix 6. Mass Transport Introduction Transport Systems Diffusion Through a Membrane Significance of Diffusion Significance of Osmosis Problems Answers Key Points Clinical Questions 7. Complexation and Protein Binding Introduction Types of Complexes Metal-Ion Coordinate Complexes Cyclodextrin Complexes Ion-Exchange Resins Protein-Ligand Interactions Plasma Protein Binding Problems Answers Key Points Clinical Questions Appendix 8. Dispersed Systems Dispersed Systems Classified by Their Phases Dispersed Systems Classified by Their Particle Size Physical Stability of Dispersed Systems Summary Problems Answers Key Points Clinical Questions Suggested Readings 9. Interfacial Phenomena Surface Tension Electrical Double Layer Adsorption Problems Answers Key Points Clinical Questions Appendix 10. Rheology Introduction Newtonian Flow Viscosity of Newtonian Fluids Effect of Temperature on Viscosity Non-Newtonian Flow Thixotropy Viscoelasticity Significance of Rheology Viscosity Modifiers Problems Answers Key Points Clinical Questions Appendix 11. Chemical Kinetics of Pharmaceuticals Common Drug Degradation Reactions Order of Reaction Determination of the Order of a Reaction Stability and Shelf-Life of Drugs Enzyme Catalysis Reactions Pharmacokinetics: An Extension of Reaction Kinetics Problems Answers Clinical Questions Suggested Readings Appendix: Basic Mathematical Concepts Equations Logarithmic Function Exponential Function Differentiation and Integration Functions Bibliography Mathematical Tables Endnotes Index
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