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Providing a concise, yet comprehensive, reference on all aspects of industrial exposures and toxicants; this book aids toxicologists, industrial hygienists, and occupational physicians to investigate workplace health problems.
- Updates and expands coverage with new chapters covering regulatory toxicology, toxicity testing, physical hazards, high production volume (HPV) chemicals, and workplace drug use - Includes information on occupational and environmental sources of exposure, mammalian toxicology, industrial hygiene, medical management and ecotoxicology - Retains a succinct chapter…mehr
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Providing a concise, yet comprehensive, reference on all aspects of industrial exposures and toxicants; this book aids toxicologists, industrial hygienists, and occupational physicians to investigate workplace health problems.
- Updates and expands coverage with new chapters covering regulatory toxicology, toxicity testing, physical hazards, high production volume (HPV) chemicals, and workplace drug use
- Includes information on occupational and environmental sources of exposure, mammalian toxicology, industrial hygiene, medical management and ecotoxicology
- Retains a succinct chapter format that has become the hallmark for the previous editions
- Distils a vast amount of information into one resource for both academics and professionals
Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
- Updates and expands coverage with new chapters covering regulatory toxicology, toxicity testing, physical hazards, high production volume (HPV) chemicals, and workplace drug use
- Includes information on occupational and environmental sources of exposure, mammalian toxicology, industrial hygiene, medical management and ecotoxicology
- Retains a succinct chapter format that has become the hallmark for the previous editions
- Distils a vast amount of information into one resource for both academics and professionals
Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
Produktdetails
- Produktdetails
- Verlag: Wiley & Sons
- Artikelnr. des Verlages: 14592973000
- 6. Aufl.
- Seitenzahl: 1376
- Erscheinungstermin: 13. April 2015
- Englisch
- Abmessung: 287mm x 222mm x 58mm
- Gewicht: 3012g
- ISBN-13: 9780470929735
- ISBN-10: 0470929731
- Artikelnr.: 42054705
- Verlag: Wiley & Sons
- Artikelnr. des Verlages: 14592973000
- 6. Aufl.
- Seitenzahl: 1376
- Erscheinungstermin: 13. April 2015
- Englisch
- Abmessung: 287mm x 222mm x 58mm
- Gewicht: 3012g
- ISBN-13: 9780470929735
- ISBN-10: 0470929731
- Artikelnr.: 42054705
Raymond Harbison is a Professor of Environmental and Occupational Health and of Pathology and Pharmacology at the University of South Florida. He has more than thirty years of experience as a toxicologist, pharmacologist, and human health risk assessor. Marie Bourgeois is a Research Assistant Professor at University of South Florida. With Masters and Doctorate degrees in Toxicology and Risk Assessment, she teaches undergraduate courses related to environmental, occupational, and public health. Giffe Johnson is a Research Assistant Professor at University of South Florida. He has published and presented research on a variety of topics related to environmental and occupational health.
CONTRIBUTORS xiii ABBREVIATIONS xvii THE HERITAGE OF ALICE HAMILTON MD AND
HARRIET HARDY MD xix IN MEMORY xxi PREFACE xxiii SECTION I INTRODUCTION 1
Section Editor: Raymond D. Harbison 1 The Modern Approach to the Diagnosis
of Occupational Disease 3 Raymond D. Harbison and Jeffrey H. Mandel 2
Controls of Occupational Diseases 13 Daniel A. Newfang, Giffe T. Johnson,
and Raymond D. Harbison SECTION II METALS AND METALLOIDS 19 Section Editor:
Richard V. Lee 3 Introduction 21 Richard V. Lee 4 Alkali Compounds 25 Steve
Morris and Ann Lurati 5 Aluminum 33 Giffe T. Johnson 6 Antimony 39 Marie M.
Bourgeois 7 Arsenic 45 Janice S. Lee and Santhini Ramasamy 8 Barium 57
Marie M. Bourgeois 9 Beryllium 63 Alison J. Abritis and Raymond D. Harbison
10 Bismuth and Related Compounds 73 Paul Jonmaire 11 Boron 79 Giffe T.
Johnson 12 Cadmium 85 Frank D. Stephen 13 Chromium 95 Kathleen Macmahon 14
Cobalt 101 Davinderjit Singh and Raymond D. Harbison 15 Copper 109 Marie M.
Bourgeois 16 Gallium and Indium 115 Jayme P. Coyle and Raymond D. Harbison
17 Germanium 119 Marek Banasik 18 Gold 123 Marek Banasik 19 Iron 127 Steve
Morris and Jayme P. Coyle 20 Lead 131 Frank D. Stephen 21 Lithium 141
Ushang Desai 22 Manganese 149 Alex Lebeau 23 Mercury 157 Frank D. Stephen
24 Molybdenum 167 Paul Jonmaire 25 Nickel 173 Robyn L. Prueitt and Julie E.
Goodman 26 Tantalum and Niobium 183 Jayme P. Coyle and Raymond D. Harbison
27 Platinum Group Elements: Palladium, Iridium, Osmium, Rhodium, and
Ruthenium 187 Alex Lebeau 28 Platinum 193 Alex Lebeau 29 Rare Earth Metals
199 Raymond D. Harbison and David R. Johnson 30 Selenium and its Compounds
205 Anna M. Fan and Marco Vinceti 31 Silver 229 Giffe T. Johnson 32
Tellurium 233 Marek Banasik 33 Thallium 239 Nikolay M. Filipov 34 Tin 247
Raymond D. Harbison and David R. Johnson 35 Titanium 253 Ushang Desai and
Raymond D. Harbison 36 Tungsten 257 Kambria K. Haire and Raymond D.
Harbison 37 Vanadium 261 James C. Ball and Maureen R. Gwinn 38 Zinc 277
Giffe T. Johnson 39 Hafnium and Zirconium 283 Kambria K. Haire, Jayme P.
Coyle, and Raymond D. Harbison 40 Metal Fume Fever and Metal-Related Lung
Disease 289 Thomas Truncale SECTION III CHEMICAL COMPOUNDS I 301 Section
Editor: Raymond D. Harbison 41 Introduction 303 Raymond D. Harbison 42
Carbon Dioxide 305 Debra J. Price 43 Carbon Monoxide 309 Erin L. Pulster
and James V. Hillman 44 Carbon Disulfide 317 Debra J. Price 45 Hydrogen
Sulfide 325 Stephen C. Harbison and Jacob R. Bourgeois 46 Cyanide 331 Erin
L. Pulster and James V. Hillman 47 Halogens 341 Joseph A. Puccio 48
Phosgene 357 Benjamin Wong, Michael W. Perkins, and Alfred M. Sciuto 49
Nitrogen Compounds 363 Kathleen T. Jenkins 50 Oxygen and Ozone 371 Robert
A. Klocke 51 Phosphorus Compounds 383 M. Rony Francois and Frank Stephen 52
Sulfur Compounds 391 Frank Stephen and M. Rony Francois SECTION IV ORGANIC
COMPOUNDS 401 Section Editor: Raymond D. Harbison 53 Aliphatic Hydrocarbons
403 Mayowa Amosu, Nicole Nation, and Mary Alice Smith 54 Alcohols and
Glycols 419 Kelly W. Hall 55 Aldehydes and Ketones 445 Jason S. Garcia and
Raymond D. Harbison 56 Ethers and Epoxides 491 Erin L. Pulster, Jacob R.
Bourgeois, and Raymond D. Harbison 57 Esters 505 Raymond D. Harbison and C.
Clifford Conaway 58 Chlorinated Hydrocarbons 541 Michael H. Lumpkin 59
Other Halogenated Hydrocarbons 567 Michael H. Lumpkin 60 Aromatic
Hydrocarbons 581 Raymond D. Harbison, Amora Mayo-Perez, David R. Johnson,
and Marie M. Bourgeois 61 Amino and Nitro Compounds 615 David Y. Lai and
Yin-Tak Woo 62 Methyl Tert-Butyl Ether (MTBE) 643 Janice S. Lee and Robyn
Blain 63 Ethyl Tertiary Butyl Ether (ETBE) 651 Keith D. Salazar 64
tert-Butyl Alcohol 657 Janice S. Lee 65 Naphthalene 663 Lisa A. Bailey,
Laura E. Kerper, and Lorenz R. Rhomberg 66 Gasoline (Petrol, Motor Spirits,
Motor Fuel, Natural Gasoline, Benzin, Mogas) 669 Raymond D. Harbison and
Daniel A. Newfang 67 1-Bromopropane 677 Marek Banasik 68 Diacetyl 683 David
J. Hewitt 69 Perfluoroalkyl Compounds 689 Jason S. Garcia and Raymond D.
Harbison 70 Tetrahydrofuran 719 Ghazi A. Dannan 71 Perchloroethylene
(Tetrachloroethylene) 727 David G. Dodge and Julie E. Goodman 72
Trichloroethylene 733 David G. Dodge and Julie E. Goodman 73 Acrylonitrile
741 Jason M. Fritz and April M. Luke SECTION V ORGANIC HIGH POLYMERS,
MONOMERS, AND POLYMER ADDITIVES 755 Section Editor: Raymond D. Harbison 74
Introduction 757 Raymond D. Harbison 75 Plastics 759 Marek Banasik 76
Elastomers 785 Marek Banasik 77 Synthetic Fibers 791 Marek Banasik 78
Bisphenol A (4,4¿-Isopropylidenediphenol) 795 Julie E. Goodman, Lorenz R.
Rhomberg, and Michael K. Peterson 79 Polystyrene/Styrene 809 Leslie A.
Beyer and Julie E. Goodman 80 Phthalates 815 Robert W. Benson 81
Decabromodiphenyl Ethane 821 Marek Banasik 82 Tetrabromobisphenol A 827
David Y. Lai 83 Tris[2-Chloro-1-(Chloromethyl)Ethyl] Phosphate (TDCPP) 837
Marek Banasik 84 Tris(2-Chloro-1-Methylethyl) Phosphate (TCPP) 845 Marek
Banasik SECTION VI PESTICIDES 855 Section Editor: Raymond D. Harbison 85
Introduction 857 Raymond D. Harbison 86 Insecticides 859 Carol S. Wood 87
Herbicides 877 Giffe T. Johnson 88 Fungicides 901 Amora Mayo-Perez and
Raymond D. Harbison 89 Rodenticides 917 Daniel L. Sudakin SECTION VII DUSTS
AND FIBERS 927 Section Editor: Raymond D. Harbison 90 Introduction 929
David R. Johnson 91 Benign Dusts (Nuisance Dusts) 931 Humairat H. Rahman
and Raymond D. Harbison 92 Fibrogenic Dusts 935 Charles Barton 93 Mixed
Dusts 949 Charles Barton 94 Synthetic Vitreous Fibers 959 Thomas Truncale
and Yehia Y. Hammad 95 Organic Dusts 969 David R. Johnson 96 Naturally
Occurring Mineral Fibers 997 Ali K. Hamade, Christopher M. Long, and Peter
A. Valberg 97 Nanoparticles 1025 Daniel A. Newfang, Giffe T. Johnson, and
Raymond D. Harbison SECTION VIII PHYSICAL AGENTS 1029 Section Editor: Marie
Bourgeois 98 Radio-Frequency Radiation 1031 R. Timothy Hitchcock 99 Optical
Radiation: Ultraviolet, Visible Light, Infrared, and Lasers 1045 Joseph M.
Greco 100 Ionizing Radiation 1055 Thomas A. Lewandowski, Juhi K. Chandalia,
and Peter A. Valberg 101 Electromagnetic Waves (EMF and RF) and Health
Effects 1069 Peter A. Valberg 102 Traumatogens Associated with Carpal
Tunnel Syndrome 1087 Joan M. Watkins 103 Vibration 1099 Donald E. Wasserman
104 Occupational Noise 1115 David L. Dahlstrom 105 Heat Stress Illness 1123
Marie M. Bourgeois and David R. Johnson SECTION IX SPECIAL TOPICS 1129
Section Editor: Raymond D. Harbison 106 Mode of Action/Human Relevance
Framework 1131 M.E. (Bette) Meek 107 Carcinogenesis 1135 Carlos A.
Muro-Cacho 108 Genotoxicity Testing Strategies, Guidelines, and Methods
1173 Ching-hung Hsu and Qingli Wang 109 Human Relevance of Rodent Leydig
Cell Tumors 1189 Thomas J. Steinbach, Robert. R. Maronpot, and Jerry F.
Hardisty 110 Reproductive Toxicology 1197 Judith W. Henck 111 Developmental
Toxicology 1229 Thomas A. Lewandowski 112 Ototoxicity 1241 Matthew Mifsud
and K. Paul Boyev 113 Dermal and Ocular Toxicity 1247 Jayme P. Coyle,
Alison J. Abritis, Amora Mayo-Perez, Marie M. Bourgeois, and Raymond D.
Harbison 114 Reactive Airways Dysfunction Syndrome (RADS) 1259 David J.
Hewitt 115 Pulmonary Sensitization 1263 David J. Hewitt 116 "Street" and
Prescription Drug Abuse 1267 Sharon S. Kelley, James Godin, and John
Christie 117 Mycotoxins 1283 Clara Y. Chan and Bruce J. Kelman 118
Phosphine 1295 Michael W. Perkins, Benjamin Wong, Dorian Olivera, and
Alfred Sciuto 119 Diesel Exhaust 1301 J. Michael Berg, Phillip T. Goad, and
Thomas W. Hesterberg 120 Spaceflight Operations 1311 Michael A. Cardinale,
Philip J. Scarpa, James R. Taffer, and Daniel Woodard 121 Regulatory
Toxicology 1321 David M. Polanic and Marek Banasik INDEX 1331
HARRIET HARDY MD xix IN MEMORY xxi PREFACE xxiii SECTION I INTRODUCTION 1
Section Editor: Raymond D. Harbison 1 The Modern Approach to the Diagnosis
of Occupational Disease 3 Raymond D. Harbison and Jeffrey H. Mandel 2
Controls of Occupational Diseases 13 Daniel A. Newfang, Giffe T. Johnson,
and Raymond D. Harbison SECTION II METALS AND METALLOIDS 19 Section Editor:
Richard V. Lee 3 Introduction 21 Richard V. Lee 4 Alkali Compounds 25 Steve
Morris and Ann Lurati 5 Aluminum 33 Giffe T. Johnson 6 Antimony 39 Marie M.
Bourgeois 7 Arsenic 45 Janice S. Lee and Santhini Ramasamy 8 Barium 57
Marie M. Bourgeois 9 Beryllium 63 Alison J. Abritis and Raymond D. Harbison
10 Bismuth and Related Compounds 73 Paul Jonmaire 11 Boron 79 Giffe T.
Johnson 12 Cadmium 85 Frank D. Stephen 13 Chromium 95 Kathleen Macmahon 14
Cobalt 101 Davinderjit Singh and Raymond D. Harbison 15 Copper 109 Marie M.
Bourgeois 16 Gallium and Indium 115 Jayme P. Coyle and Raymond D. Harbison
17 Germanium 119 Marek Banasik 18 Gold 123 Marek Banasik 19 Iron 127 Steve
Morris and Jayme P. Coyle 20 Lead 131 Frank D. Stephen 21 Lithium 141
Ushang Desai 22 Manganese 149 Alex Lebeau 23 Mercury 157 Frank D. Stephen
24 Molybdenum 167 Paul Jonmaire 25 Nickel 173 Robyn L. Prueitt and Julie E.
Goodman 26 Tantalum and Niobium 183 Jayme P. Coyle and Raymond D. Harbison
27 Platinum Group Elements: Palladium, Iridium, Osmium, Rhodium, and
Ruthenium 187 Alex Lebeau 28 Platinum 193 Alex Lebeau 29 Rare Earth Metals
199 Raymond D. Harbison and David R. Johnson 30 Selenium and its Compounds
205 Anna M. Fan and Marco Vinceti 31 Silver 229 Giffe T. Johnson 32
Tellurium 233 Marek Banasik 33 Thallium 239 Nikolay M. Filipov 34 Tin 247
Raymond D. Harbison and David R. Johnson 35 Titanium 253 Ushang Desai and
Raymond D. Harbison 36 Tungsten 257 Kambria K. Haire and Raymond D.
Harbison 37 Vanadium 261 James C. Ball and Maureen R. Gwinn 38 Zinc 277
Giffe T. Johnson 39 Hafnium and Zirconium 283 Kambria K. Haire, Jayme P.
Coyle, and Raymond D. Harbison 40 Metal Fume Fever and Metal-Related Lung
Disease 289 Thomas Truncale SECTION III CHEMICAL COMPOUNDS I 301 Section
Editor: Raymond D. Harbison 41 Introduction 303 Raymond D. Harbison 42
Carbon Dioxide 305 Debra J. Price 43 Carbon Monoxide 309 Erin L. Pulster
and James V. Hillman 44 Carbon Disulfide 317 Debra J. Price 45 Hydrogen
Sulfide 325 Stephen C. Harbison and Jacob R. Bourgeois 46 Cyanide 331 Erin
L. Pulster and James V. Hillman 47 Halogens 341 Joseph A. Puccio 48
Phosgene 357 Benjamin Wong, Michael W. Perkins, and Alfred M. Sciuto 49
Nitrogen Compounds 363 Kathleen T. Jenkins 50 Oxygen and Ozone 371 Robert
A. Klocke 51 Phosphorus Compounds 383 M. Rony Francois and Frank Stephen 52
Sulfur Compounds 391 Frank Stephen and M. Rony Francois SECTION IV ORGANIC
COMPOUNDS 401 Section Editor: Raymond D. Harbison 53 Aliphatic Hydrocarbons
403 Mayowa Amosu, Nicole Nation, and Mary Alice Smith 54 Alcohols and
Glycols 419 Kelly W. Hall 55 Aldehydes and Ketones 445 Jason S. Garcia and
Raymond D. Harbison 56 Ethers and Epoxides 491 Erin L. Pulster, Jacob R.
Bourgeois, and Raymond D. Harbison 57 Esters 505 Raymond D. Harbison and C.
Clifford Conaway 58 Chlorinated Hydrocarbons 541 Michael H. Lumpkin 59
Other Halogenated Hydrocarbons 567 Michael H. Lumpkin 60 Aromatic
Hydrocarbons 581 Raymond D. Harbison, Amora Mayo-Perez, David R. Johnson,
and Marie M. Bourgeois 61 Amino and Nitro Compounds 615 David Y. Lai and
Yin-Tak Woo 62 Methyl Tert-Butyl Ether (MTBE) 643 Janice S. Lee and Robyn
Blain 63 Ethyl Tertiary Butyl Ether (ETBE) 651 Keith D. Salazar 64
tert-Butyl Alcohol 657 Janice S. Lee 65 Naphthalene 663 Lisa A. Bailey,
Laura E. Kerper, and Lorenz R. Rhomberg 66 Gasoline (Petrol, Motor Spirits,
Motor Fuel, Natural Gasoline, Benzin, Mogas) 669 Raymond D. Harbison and
Daniel A. Newfang 67 1-Bromopropane 677 Marek Banasik 68 Diacetyl 683 David
J. Hewitt 69 Perfluoroalkyl Compounds 689 Jason S. Garcia and Raymond D.
Harbison 70 Tetrahydrofuran 719 Ghazi A. Dannan 71 Perchloroethylene
(Tetrachloroethylene) 727 David G. Dodge and Julie E. Goodman 72
Trichloroethylene 733 David G. Dodge and Julie E. Goodman 73 Acrylonitrile
741 Jason M. Fritz and April M. Luke SECTION V ORGANIC HIGH POLYMERS,
MONOMERS, AND POLYMER ADDITIVES 755 Section Editor: Raymond D. Harbison 74
Introduction 757 Raymond D. Harbison 75 Plastics 759 Marek Banasik 76
Elastomers 785 Marek Banasik 77 Synthetic Fibers 791 Marek Banasik 78
Bisphenol A (4,4¿-Isopropylidenediphenol) 795 Julie E. Goodman, Lorenz R.
Rhomberg, and Michael K. Peterson 79 Polystyrene/Styrene 809 Leslie A.
Beyer and Julie E. Goodman 80 Phthalates 815 Robert W. Benson 81
Decabromodiphenyl Ethane 821 Marek Banasik 82 Tetrabromobisphenol A 827
David Y. Lai 83 Tris[2-Chloro-1-(Chloromethyl)Ethyl] Phosphate (TDCPP) 837
Marek Banasik 84 Tris(2-Chloro-1-Methylethyl) Phosphate (TCPP) 845 Marek
Banasik SECTION VI PESTICIDES 855 Section Editor: Raymond D. Harbison 85
Introduction 857 Raymond D. Harbison 86 Insecticides 859 Carol S. Wood 87
Herbicides 877 Giffe T. Johnson 88 Fungicides 901 Amora Mayo-Perez and
Raymond D. Harbison 89 Rodenticides 917 Daniel L. Sudakin SECTION VII DUSTS
AND FIBERS 927 Section Editor: Raymond D. Harbison 90 Introduction 929
David R. Johnson 91 Benign Dusts (Nuisance Dusts) 931 Humairat H. Rahman
and Raymond D. Harbison 92 Fibrogenic Dusts 935 Charles Barton 93 Mixed
Dusts 949 Charles Barton 94 Synthetic Vitreous Fibers 959 Thomas Truncale
and Yehia Y. Hammad 95 Organic Dusts 969 David R. Johnson 96 Naturally
Occurring Mineral Fibers 997 Ali K. Hamade, Christopher M. Long, and Peter
A. Valberg 97 Nanoparticles 1025 Daniel A. Newfang, Giffe T. Johnson, and
Raymond D. Harbison SECTION VIII PHYSICAL AGENTS 1029 Section Editor: Marie
Bourgeois 98 Radio-Frequency Radiation 1031 R. Timothy Hitchcock 99 Optical
Radiation: Ultraviolet, Visible Light, Infrared, and Lasers 1045 Joseph M.
Greco 100 Ionizing Radiation 1055 Thomas A. Lewandowski, Juhi K. Chandalia,
and Peter A. Valberg 101 Electromagnetic Waves (EMF and RF) and Health
Effects 1069 Peter A. Valberg 102 Traumatogens Associated with Carpal
Tunnel Syndrome 1087 Joan M. Watkins 103 Vibration 1099 Donald E. Wasserman
104 Occupational Noise 1115 David L. Dahlstrom 105 Heat Stress Illness 1123
Marie M. Bourgeois and David R. Johnson SECTION IX SPECIAL TOPICS 1129
Section Editor: Raymond D. Harbison 106 Mode of Action/Human Relevance
Framework 1131 M.E. (Bette) Meek 107 Carcinogenesis 1135 Carlos A.
Muro-Cacho 108 Genotoxicity Testing Strategies, Guidelines, and Methods
1173 Ching-hung Hsu and Qingli Wang 109 Human Relevance of Rodent Leydig
Cell Tumors 1189 Thomas J. Steinbach, Robert. R. Maronpot, and Jerry F.
Hardisty 110 Reproductive Toxicology 1197 Judith W. Henck 111 Developmental
Toxicology 1229 Thomas A. Lewandowski 112 Ototoxicity 1241 Matthew Mifsud
and K. Paul Boyev 113 Dermal and Ocular Toxicity 1247 Jayme P. Coyle,
Alison J. Abritis, Amora Mayo-Perez, Marie M. Bourgeois, and Raymond D.
Harbison 114 Reactive Airways Dysfunction Syndrome (RADS) 1259 David J.
Hewitt 115 Pulmonary Sensitization 1263 David J. Hewitt 116 "Street" and
Prescription Drug Abuse 1267 Sharon S. Kelley, James Godin, and John
Christie 117 Mycotoxins 1283 Clara Y. Chan and Bruce J. Kelman 118
Phosphine 1295 Michael W. Perkins, Benjamin Wong, Dorian Olivera, and
Alfred Sciuto 119 Diesel Exhaust 1301 J. Michael Berg, Phillip T. Goad, and
Thomas W. Hesterberg 120 Spaceflight Operations 1311 Michael A. Cardinale,
Philip J. Scarpa, James R. Taffer, and Daniel Woodard 121 Regulatory
Toxicology 1321 David M. Polanic and Marek Banasik INDEX 1331
CONTRIBUTORS xiii ABBREVIATIONS xvii THE HERITAGE OF ALICE HAMILTON MD AND
HARRIET HARDY MD xix IN MEMORY xxi PREFACE xxiii SECTION I INTRODUCTION 1
Section Editor: Raymond D. Harbison 1 The Modern Approach to the Diagnosis
of Occupational Disease 3 Raymond D. Harbison and Jeffrey H. Mandel 2
Controls of Occupational Diseases 13 Daniel A. Newfang, Giffe T. Johnson,
and Raymond D. Harbison SECTION II METALS AND METALLOIDS 19 Section Editor:
Richard V. Lee 3 Introduction 21 Richard V. Lee 4 Alkali Compounds 25 Steve
Morris and Ann Lurati 5 Aluminum 33 Giffe T. Johnson 6 Antimony 39 Marie M.
Bourgeois 7 Arsenic 45 Janice S. Lee and Santhini Ramasamy 8 Barium 57
Marie M. Bourgeois 9 Beryllium 63 Alison J. Abritis and Raymond D. Harbison
10 Bismuth and Related Compounds 73 Paul Jonmaire 11 Boron 79 Giffe T.
Johnson 12 Cadmium 85 Frank D. Stephen 13 Chromium 95 Kathleen Macmahon 14
Cobalt 101 Davinderjit Singh and Raymond D. Harbison 15 Copper 109 Marie M.
Bourgeois 16 Gallium and Indium 115 Jayme P. Coyle and Raymond D. Harbison
17 Germanium 119 Marek Banasik 18 Gold 123 Marek Banasik 19 Iron 127 Steve
Morris and Jayme P. Coyle 20 Lead 131 Frank D. Stephen 21 Lithium 141
Ushang Desai 22 Manganese 149 Alex Lebeau 23 Mercury 157 Frank D. Stephen
24 Molybdenum 167 Paul Jonmaire 25 Nickel 173 Robyn L. Prueitt and Julie E.
Goodman 26 Tantalum and Niobium 183 Jayme P. Coyle and Raymond D. Harbison
27 Platinum Group Elements: Palladium, Iridium, Osmium, Rhodium, and
Ruthenium 187 Alex Lebeau 28 Platinum 193 Alex Lebeau 29 Rare Earth Metals
199 Raymond D. Harbison and David R. Johnson 30 Selenium and its Compounds
205 Anna M. Fan and Marco Vinceti 31 Silver 229 Giffe T. Johnson 32
Tellurium 233 Marek Banasik 33 Thallium 239 Nikolay M. Filipov 34 Tin 247
Raymond D. Harbison and David R. Johnson 35 Titanium 253 Ushang Desai and
Raymond D. Harbison 36 Tungsten 257 Kambria K. Haire and Raymond D.
Harbison 37 Vanadium 261 James C. Ball and Maureen R. Gwinn 38 Zinc 277
Giffe T. Johnson 39 Hafnium and Zirconium 283 Kambria K. Haire, Jayme P.
Coyle, and Raymond D. Harbison 40 Metal Fume Fever and Metal-Related Lung
Disease 289 Thomas Truncale SECTION III CHEMICAL COMPOUNDS I 301 Section
Editor: Raymond D. Harbison 41 Introduction 303 Raymond D. Harbison 42
Carbon Dioxide 305 Debra J. Price 43 Carbon Monoxide 309 Erin L. Pulster
and James V. Hillman 44 Carbon Disulfide 317 Debra J. Price 45 Hydrogen
Sulfide 325 Stephen C. Harbison and Jacob R. Bourgeois 46 Cyanide 331 Erin
L. Pulster and James V. Hillman 47 Halogens 341 Joseph A. Puccio 48
Phosgene 357 Benjamin Wong, Michael W. Perkins, and Alfred M. Sciuto 49
Nitrogen Compounds 363 Kathleen T. Jenkins 50 Oxygen and Ozone 371 Robert
A. Klocke 51 Phosphorus Compounds 383 M. Rony Francois and Frank Stephen 52
Sulfur Compounds 391 Frank Stephen and M. Rony Francois SECTION IV ORGANIC
COMPOUNDS 401 Section Editor: Raymond D. Harbison 53 Aliphatic Hydrocarbons
403 Mayowa Amosu, Nicole Nation, and Mary Alice Smith 54 Alcohols and
Glycols 419 Kelly W. Hall 55 Aldehydes and Ketones 445 Jason S. Garcia and
Raymond D. Harbison 56 Ethers and Epoxides 491 Erin L. Pulster, Jacob R.
Bourgeois, and Raymond D. Harbison 57 Esters 505 Raymond D. Harbison and C.
Clifford Conaway 58 Chlorinated Hydrocarbons 541 Michael H. Lumpkin 59
Other Halogenated Hydrocarbons 567 Michael H. Lumpkin 60 Aromatic
Hydrocarbons 581 Raymond D. Harbison, Amora Mayo-Perez, David R. Johnson,
and Marie M. Bourgeois 61 Amino and Nitro Compounds 615 David Y. Lai and
Yin-Tak Woo 62 Methyl Tert-Butyl Ether (MTBE) 643 Janice S. Lee and Robyn
Blain 63 Ethyl Tertiary Butyl Ether (ETBE) 651 Keith D. Salazar 64
tert-Butyl Alcohol 657 Janice S. Lee 65 Naphthalene 663 Lisa A. Bailey,
Laura E. Kerper, and Lorenz R. Rhomberg 66 Gasoline (Petrol, Motor Spirits,
Motor Fuel, Natural Gasoline, Benzin, Mogas) 669 Raymond D. Harbison and
Daniel A. Newfang 67 1-Bromopropane 677 Marek Banasik 68 Diacetyl 683 David
J. Hewitt 69 Perfluoroalkyl Compounds 689 Jason S. Garcia and Raymond D.
Harbison 70 Tetrahydrofuran 719 Ghazi A. Dannan 71 Perchloroethylene
(Tetrachloroethylene) 727 David G. Dodge and Julie E. Goodman 72
Trichloroethylene 733 David G. Dodge and Julie E. Goodman 73 Acrylonitrile
741 Jason M. Fritz and April M. Luke SECTION V ORGANIC HIGH POLYMERS,
MONOMERS, AND POLYMER ADDITIVES 755 Section Editor: Raymond D. Harbison 74
Introduction 757 Raymond D. Harbison 75 Plastics 759 Marek Banasik 76
Elastomers 785 Marek Banasik 77 Synthetic Fibers 791 Marek Banasik 78
Bisphenol A (4,4¿-Isopropylidenediphenol) 795 Julie E. Goodman, Lorenz R.
Rhomberg, and Michael K. Peterson 79 Polystyrene/Styrene 809 Leslie A.
Beyer and Julie E. Goodman 80 Phthalates 815 Robert W. Benson 81
Decabromodiphenyl Ethane 821 Marek Banasik 82 Tetrabromobisphenol A 827
David Y. Lai 83 Tris[2-Chloro-1-(Chloromethyl)Ethyl] Phosphate (TDCPP) 837
Marek Banasik 84 Tris(2-Chloro-1-Methylethyl) Phosphate (TCPP) 845 Marek
Banasik SECTION VI PESTICIDES 855 Section Editor: Raymond D. Harbison 85
Introduction 857 Raymond D. Harbison 86 Insecticides 859 Carol S. Wood 87
Herbicides 877 Giffe T. Johnson 88 Fungicides 901 Amora Mayo-Perez and
Raymond D. Harbison 89 Rodenticides 917 Daniel L. Sudakin SECTION VII DUSTS
AND FIBERS 927 Section Editor: Raymond D. Harbison 90 Introduction 929
David R. Johnson 91 Benign Dusts (Nuisance Dusts) 931 Humairat H. Rahman
and Raymond D. Harbison 92 Fibrogenic Dusts 935 Charles Barton 93 Mixed
Dusts 949 Charles Barton 94 Synthetic Vitreous Fibers 959 Thomas Truncale
and Yehia Y. Hammad 95 Organic Dusts 969 David R. Johnson 96 Naturally
Occurring Mineral Fibers 997 Ali K. Hamade, Christopher M. Long, and Peter
A. Valberg 97 Nanoparticles 1025 Daniel A. Newfang, Giffe T. Johnson, and
Raymond D. Harbison SECTION VIII PHYSICAL AGENTS 1029 Section Editor: Marie
Bourgeois 98 Radio-Frequency Radiation 1031 R. Timothy Hitchcock 99 Optical
Radiation: Ultraviolet, Visible Light, Infrared, and Lasers 1045 Joseph M.
Greco 100 Ionizing Radiation 1055 Thomas A. Lewandowski, Juhi K. Chandalia,
and Peter A. Valberg 101 Electromagnetic Waves (EMF and RF) and Health
Effects 1069 Peter A. Valberg 102 Traumatogens Associated with Carpal
Tunnel Syndrome 1087 Joan M. Watkins 103 Vibration 1099 Donald E. Wasserman
104 Occupational Noise 1115 David L. Dahlstrom 105 Heat Stress Illness 1123
Marie M. Bourgeois and David R. Johnson SECTION IX SPECIAL TOPICS 1129
Section Editor: Raymond D. Harbison 106 Mode of Action/Human Relevance
Framework 1131 M.E. (Bette) Meek 107 Carcinogenesis 1135 Carlos A.
Muro-Cacho 108 Genotoxicity Testing Strategies, Guidelines, and Methods
1173 Ching-hung Hsu and Qingli Wang 109 Human Relevance of Rodent Leydig
Cell Tumors 1189 Thomas J. Steinbach, Robert. R. Maronpot, and Jerry F.
Hardisty 110 Reproductive Toxicology 1197 Judith W. Henck 111 Developmental
Toxicology 1229 Thomas A. Lewandowski 112 Ototoxicity 1241 Matthew Mifsud
and K. Paul Boyev 113 Dermal and Ocular Toxicity 1247 Jayme P. Coyle,
Alison J. Abritis, Amora Mayo-Perez, Marie M. Bourgeois, and Raymond D.
Harbison 114 Reactive Airways Dysfunction Syndrome (RADS) 1259 David J.
Hewitt 115 Pulmonary Sensitization 1263 David J. Hewitt 116 "Street" and
Prescription Drug Abuse 1267 Sharon S. Kelley, James Godin, and John
Christie 117 Mycotoxins 1283 Clara Y. Chan and Bruce J. Kelman 118
Phosphine 1295 Michael W. Perkins, Benjamin Wong, Dorian Olivera, and
Alfred Sciuto 119 Diesel Exhaust 1301 J. Michael Berg, Phillip T. Goad, and
Thomas W. Hesterberg 120 Spaceflight Operations 1311 Michael A. Cardinale,
Philip J. Scarpa, James R. Taffer, and Daniel Woodard 121 Regulatory
Toxicology 1321 David M. Polanic and Marek Banasik INDEX 1331
HARRIET HARDY MD xix IN MEMORY xxi PREFACE xxiii SECTION I INTRODUCTION 1
Section Editor: Raymond D. Harbison 1 The Modern Approach to the Diagnosis
of Occupational Disease 3 Raymond D. Harbison and Jeffrey H. Mandel 2
Controls of Occupational Diseases 13 Daniel A. Newfang, Giffe T. Johnson,
and Raymond D. Harbison SECTION II METALS AND METALLOIDS 19 Section Editor:
Richard V. Lee 3 Introduction 21 Richard V. Lee 4 Alkali Compounds 25 Steve
Morris and Ann Lurati 5 Aluminum 33 Giffe T. Johnson 6 Antimony 39 Marie M.
Bourgeois 7 Arsenic 45 Janice S. Lee and Santhini Ramasamy 8 Barium 57
Marie M. Bourgeois 9 Beryllium 63 Alison J. Abritis and Raymond D. Harbison
10 Bismuth and Related Compounds 73 Paul Jonmaire 11 Boron 79 Giffe T.
Johnson 12 Cadmium 85 Frank D. Stephen 13 Chromium 95 Kathleen Macmahon 14
Cobalt 101 Davinderjit Singh and Raymond D. Harbison 15 Copper 109 Marie M.
Bourgeois 16 Gallium and Indium 115 Jayme P. Coyle and Raymond D. Harbison
17 Germanium 119 Marek Banasik 18 Gold 123 Marek Banasik 19 Iron 127 Steve
Morris and Jayme P. Coyle 20 Lead 131 Frank D. Stephen 21 Lithium 141
Ushang Desai 22 Manganese 149 Alex Lebeau 23 Mercury 157 Frank D. Stephen
24 Molybdenum 167 Paul Jonmaire 25 Nickel 173 Robyn L. Prueitt and Julie E.
Goodman 26 Tantalum and Niobium 183 Jayme P. Coyle and Raymond D. Harbison
27 Platinum Group Elements: Palladium, Iridium, Osmium, Rhodium, and
Ruthenium 187 Alex Lebeau 28 Platinum 193 Alex Lebeau 29 Rare Earth Metals
199 Raymond D. Harbison and David R. Johnson 30 Selenium and its Compounds
205 Anna M. Fan and Marco Vinceti 31 Silver 229 Giffe T. Johnson 32
Tellurium 233 Marek Banasik 33 Thallium 239 Nikolay M. Filipov 34 Tin 247
Raymond D. Harbison and David R. Johnson 35 Titanium 253 Ushang Desai and
Raymond D. Harbison 36 Tungsten 257 Kambria K. Haire and Raymond D.
Harbison 37 Vanadium 261 James C. Ball and Maureen R. Gwinn 38 Zinc 277
Giffe T. Johnson 39 Hafnium and Zirconium 283 Kambria K. Haire, Jayme P.
Coyle, and Raymond D. Harbison 40 Metal Fume Fever and Metal-Related Lung
Disease 289 Thomas Truncale SECTION III CHEMICAL COMPOUNDS I 301 Section
Editor: Raymond D. Harbison 41 Introduction 303 Raymond D. Harbison 42
Carbon Dioxide 305 Debra J. Price 43 Carbon Monoxide 309 Erin L. Pulster
and James V. Hillman 44 Carbon Disulfide 317 Debra J. Price 45 Hydrogen
Sulfide 325 Stephen C. Harbison and Jacob R. Bourgeois 46 Cyanide 331 Erin
L. Pulster and James V. Hillman 47 Halogens 341 Joseph A. Puccio 48
Phosgene 357 Benjamin Wong, Michael W. Perkins, and Alfred M. Sciuto 49
Nitrogen Compounds 363 Kathleen T. Jenkins 50 Oxygen and Ozone 371 Robert
A. Klocke 51 Phosphorus Compounds 383 M. Rony Francois and Frank Stephen 52
Sulfur Compounds 391 Frank Stephen and M. Rony Francois SECTION IV ORGANIC
COMPOUNDS 401 Section Editor: Raymond D. Harbison 53 Aliphatic Hydrocarbons
403 Mayowa Amosu, Nicole Nation, and Mary Alice Smith 54 Alcohols and
Glycols 419 Kelly W. Hall 55 Aldehydes and Ketones 445 Jason S. Garcia and
Raymond D. Harbison 56 Ethers and Epoxides 491 Erin L. Pulster, Jacob R.
Bourgeois, and Raymond D. Harbison 57 Esters 505 Raymond D. Harbison and C.
Clifford Conaway 58 Chlorinated Hydrocarbons 541 Michael H. Lumpkin 59
Other Halogenated Hydrocarbons 567 Michael H. Lumpkin 60 Aromatic
Hydrocarbons 581 Raymond D. Harbison, Amora Mayo-Perez, David R. Johnson,
and Marie M. Bourgeois 61 Amino and Nitro Compounds 615 David Y. Lai and
Yin-Tak Woo 62 Methyl Tert-Butyl Ether (MTBE) 643 Janice S. Lee and Robyn
Blain 63 Ethyl Tertiary Butyl Ether (ETBE) 651 Keith D. Salazar 64
tert-Butyl Alcohol 657 Janice S. Lee 65 Naphthalene 663 Lisa A. Bailey,
Laura E. Kerper, and Lorenz R. Rhomberg 66 Gasoline (Petrol, Motor Spirits,
Motor Fuel, Natural Gasoline, Benzin, Mogas) 669 Raymond D. Harbison and
Daniel A. Newfang 67 1-Bromopropane 677 Marek Banasik 68 Diacetyl 683 David
J. Hewitt 69 Perfluoroalkyl Compounds 689 Jason S. Garcia and Raymond D.
Harbison 70 Tetrahydrofuran 719 Ghazi A. Dannan 71 Perchloroethylene
(Tetrachloroethylene) 727 David G. Dodge and Julie E. Goodman 72
Trichloroethylene 733 David G. Dodge and Julie E. Goodman 73 Acrylonitrile
741 Jason M. Fritz and April M. Luke SECTION V ORGANIC HIGH POLYMERS,
MONOMERS, AND POLYMER ADDITIVES 755 Section Editor: Raymond D. Harbison 74
Introduction 757 Raymond D. Harbison 75 Plastics 759 Marek Banasik 76
Elastomers 785 Marek Banasik 77 Synthetic Fibers 791 Marek Banasik 78
Bisphenol A (4,4¿-Isopropylidenediphenol) 795 Julie E. Goodman, Lorenz R.
Rhomberg, and Michael K. Peterson 79 Polystyrene/Styrene 809 Leslie A.
Beyer and Julie E. Goodman 80 Phthalates 815 Robert W. Benson 81
Decabromodiphenyl Ethane 821 Marek Banasik 82 Tetrabromobisphenol A 827
David Y. Lai 83 Tris[2-Chloro-1-(Chloromethyl)Ethyl] Phosphate (TDCPP) 837
Marek Banasik 84 Tris(2-Chloro-1-Methylethyl) Phosphate (TCPP) 845 Marek
Banasik SECTION VI PESTICIDES 855 Section Editor: Raymond D. Harbison 85
Introduction 857 Raymond D. Harbison 86 Insecticides 859 Carol S. Wood 87
Herbicides 877 Giffe T. Johnson 88 Fungicides 901 Amora Mayo-Perez and
Raymond D. Harbison 89 Rodenticides 917 Daniel L. Sudakin SECTION VII DUSTS
AND FIBERS 927 Section Editor: Raymond D. Harbison 90 Introduction 929
David R. Johnson 91 Benign Dusts (Nuisance Dusts) 931 Humairat H. Rahman
and Raymond D. Harbison 92 Fibrogenic Dusts 935 Charles Barton 93 Mixed
Dusts 949 Charles Barton 94 Synthetic Vitreous Fibers 959 Thomas Truncale
and Yehia Y. Hammad 95 Organic Dusts 969 David R. Johnson 96 Naturally
Occurring Mineral Fibers 997 Ali K. Hamade, Christopher M. Long, and Peter
A. Valberg 97 Nanoparticles 1025 Daniel A. Newfang, Giffe T. Johnson, and
Raymond D. Harbison SECTION VIII PHYSICAL AGENTS 1029 Section Editor: Marie
Bourgeois 98 Radio-Frequency Radiation 1031 R. Timothy Hitchcock 99 Optical
Radiation: Ultraviolet, Visible Light, Infrared, and Lasers 1045 Joseph M.
Greco 100 Ionizing Radiation 1055 Thomas A. Lewandowski, Juhi K. Chandalia,
and Peter A. Valberg 101 Electromagnetic Waves (EMF and RF) and Health
Effects 1069 Peter A. Valberg 102 Traumatogens Associated with Carpal
Tunnel Syndrome 1087 Joan M. Watkins 103 Vibration 1099 Donald E. Wasserman
104 Occupational Noise 1115 David L. Dahlstrom 105 Heat Stress Illness 1123
Marie M. Bourgeois and David R. Johnson SECTION IX SPECIAL TOPICS 1129
Section Editor: Raymond D. Harbison 106 Mode of Action/Human Relevance
Framework 1131 M.E. (Bette) Meek 107 Carcinogenesis 1135 Carlos A.
Muro-Cacho 108 Genotoxicity Testing Strategies, Guidelines, and Methods
1173 Ching-hung Hsu and Qingli Wang 109 Human Relevance of Rodent Leydig
Cell Tumors 1189 Thomas J. Steinbach, Robert. R. Maronpot, and Jerry F.
Hardisty 110 Reproductive Toxicology 1197 Judith W. Henck 111 Developmental
Toxicology 1229 Thomas A. Lewandowski 112 Ototoxicity 1241 Matthew Mifsud
and K. Paul Boyev 113 Dermal and Ocular Toxicity 1247 Jayme P. Coyle,
Alison J. Abritis, Amora Mayo-Perez, Marie M. Bourgeois, and Raymond D.
Harbison 114 Reactive Airways Dysfunction Syndrome (RADS) 1259 David J.
Hewitt 115 Pulmonary Sensitization 1263 David J. Hewitt 116 "Street" and
Prescription Drug Abuse 1267 Sharon S. Kelley, James Godin, and John
Christie 117 Mycotoxins 1283 Clara Y. Chan and Bruce J. Kelman 118
Phosphine 1295 Michael W. Perkins, Benjamin Wong, Dorian Olivera, and
Alfred Sciuto 119 Diesel Exhaust 1301 J. Michael Berg, Phillip T. Goad, and
Thomas W. Hesterberg 120 Spaceflight Operations 1311 Michael A. Cardinale,
Philip J. Scarpa, James R. Taffer, and Daniel Woodard 121 Regulatory
Toxicology 1321 David M. Polanic and Marek Banasik INDEX 1331