The most comprehensive, current sickle cell disease resource-for both clinicians and researchers A Doody's Core Title for 2024 & 2023! The first and only resource of its kind, Sickle Cell Disease examines this blood disorder through both clinical and research lenses. More than 80 dedicated experts in the field present their combined clinical knowledge of basic mechanisms, screening, diagnosis, management, and treatment of myriad complex complications of a single base point mutation in the human genome. Case studies with "How I Treat" authoritative insights provide overviews of common and rare…mehr
The most comprehensive, current sickle cell disease resource-for both clinicians and researchers A Doody's Core Title for 2024 & 2023! The first and only resource of its kind, Sickle Cell Disease examines this blood disorder through both clinical and research lenses. More than 80 dedicated experts in the field present their combined clinical knowledge of basic mechanisms, screening, diagnosis, management, and treatment of myriad complex complications of a single base point mutation in the human genome. Case studies with "How I Treat" authoritative insights provide overviews of common and rare complications, and Key Facts offer at-a-glance high-yield information. Filled with clinical photos, illustrations, numerous original diagrams, and with free updates available online, this unmatched resource covers: * Mechanisms of sickle cell disease * Historic and current research approaches * The latest work in gene therapy and editing * Guidelines for patient care, diagnosis, unique cases, and therapies * Rare and common complications, including domestic and internationally relevant topics * Psychosocial and supportive care * The newest standards of therapy and future treatment options in children and adults * Cardiopulmonary complications A Doody's Core Title for 2022!Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
Mark T. Gladwin, MD, is Professor and Chairman, Department of Medicine, University of Pittsburgh, and Director, Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute. Gregory J. Kato, MD, is Professor of Medicine, Division of Hematology/Oncology, University of Pittsburgh, and Director, University of Pittsburgh's Sickle Cell Center of Excellence. Enrico M. Novelli, MD, is Associate Professor of Medicine, Division of Hematology/Oncology, University of Pittsburgh, and Director, University of Pittsburgh Medical Center's Adult Sickle Cell Disease Program.
Inhaltsangabe
Table of Contents I. Basic Mechanisms of Disease: 1. Overview: Carlo Brugnara, Betty Pace 2. Genetic basis of SCD: Martin Steinberg, SweeLay Thein 3. Hemoglobin S polymerization: Daniel Kim-Shapiro, Alan Schechter, and Constance Noguchi 4. Adhesion and vaso-occlusion - the role of leukocytes: Paul Frenette, 5. Hemolysis and endothelial dysfunction: Mark Gladwin, Gregory Kato 6. Sterile inflammation and the inflammasome: Prithu Sundd, Solomon Ofori-Acquah 7. IIschemia-reperfusion injury, inflammation and oxidative stress: Robert Hebbel, John Belcher, Gregory Vercellotti 8. Mouse models of SCD and mechanisms of pain:Cheryl Hillery, Kalpna Gupta, Lewis Hsu 9. Fetal hemoglobin induction - past, present and future: Abdullah Kutlar, Griff Rodgers II. Clinical Complications of Sickle Cell Disease: Overview: Alexis Thompson, Ken Ataga 10. Stroke and cognitive dysfunction: Fenella Kirkham, Michael DeBaun, Robert Adams 11. Pediatric complications and newborn screening: John J. Strouse, James Casella, Nancy Green 12. Airway hyperreactivity and asthma: Claudia Morris, Liz Klings 13. Acute chest syndrome:Elliott Vichinsky, Armand Mekontso-Dessap 14. Pulmonary hypertension (PH) and critical illness: Roberto Machado, Mark Gladwin 15. Heart disease: Vandana Sachdev, Punam Malik,John Wood 16. Renal: Victor Gordeuk,Santosh Saraf, Jane Little 17. Sickle cell trait: Philippe Connes, Rakhi Naik, Hyacinth Hyacinth 18. Thrombophilia in SCD: Nigel Key, Rafal Pawlinski, Enrico Novelli 19. Acute and chronic pain: Wally Smith, Samir Ballas 20. "Orphan" complications - leg ulcers and priapism: Caterina Minniti, Arthur Burnett 21. Ocular complications: : Adrienne Scott, Morton Goldberg 22. Rare presentations and emerging complications: Frédéric Galacteros, Oswaldo Castro, Kathryn Hassell 23. Globalburden of disease: new frontiers in SCD research and care: Kwaku Ohene-Frempong, Julie Makani, Fernando Costa, Graham Serjeant,Yazdi Italia III. EmergingTherapeutics: Overview: David Rees, Sophie Lanzkron 24. Transfusion medicine: Anoosha Habibi, Darrell Triulzi, Miguel Abboud, Sally Campbell Lee 25. Clinical trials - state of the art and lessons learned: Ken Ataga, Laura De Castro, Marilyn Telen 26. Stem cell transplantation: John Tisdale,Courtney Fitzhugh, Mark Walters, Lakshmanan Krishnamurti 27. Emergency care - challenges and opportunities: ClaudiaMorris 28. The psychosocial burden in SCD: MarciaTreadwell, Allison King, Julie Panepinto, Charles Jonaissant 29. Hydroxyurea and the dawn of combination therapy in SCD: Winfred Wang, Russell Ware 30. The HOLY GRAIL - Gene editing and Therapy: TimTownes, Marina Cavazzana-Calvo Additional authors: Joshua Field (chapter assignment TBD)
Table of Contents I. Basic Mechanisms of Disease: 1. Overview: Carlo Brugnara, Betty Pace 2. Genetic basis of SCD: Martin Steinberg, SweeLay Thein 3. Hemoglobin S polymerization: Daniel Kim-Shapiro, Alan Schechter, and Constance Noguchi 4. Adhesion and vaso-occlusion - the role of leukocytes: Paul Frenette, 5. Hemolysis and endothelial dysfunction: Mark Gladwin, Gregory Kato 6. Sterile inflammation and the inflammasome: Prithu Sundd, Solomon Ofori-Acquah 7. IIschemia-reperfusion injury, inflammation and oxidative stress: Robert Hebbel, John Belcher, Gregory Vercellotti 8. Mouse models of SCD and mechanisms of pain:Cheryl Hillery, Kalpna Gupta, Lewis Hsu 9. Fetal hemoglobin induction - past, present and future: Abdullah Kutlar, Griff Rodgers II. Clinical Complications of Sickle Cell Disease: Overview: Alexis Thompson, Ken Ataga 10. Stroke and cognitive dysfunction: Fenella Kirkham, Michael DeBaun, Robert Adams 11. Pediatric complications and newborn screening: John J. Strouse, James Casella, Nancy Green 12. Airway hyperreactivity and asthma: Claudia Morris, Liz Klings 13. Acute chest syndrome:Elliott Vichinsky, Armand Mekontso-Dessap 14. Pulmonary hypertension (PH) and critical illness: Roberto Machado, Mark Gladwin 15. Heart disease: Vandana Sachdev, Punam Malik,John Wood 16. Renal: Victor Gordeuk,Santosh Saraf, Jane Little 17. Sickle cell trait: Philippe Connes, Rakhi Naik, Hyacinth Hyacinth 18. Thrombophilia in SCD: Nigel Key, Rafal Pawlinski, Enrico Novelli 19. Acute and chronic pain: Wally Smith, Samir Ballas 20. "Orphan" complications - leg ulcers and priapism: Caterina Minniti, Arthur Burnett 21. Ocular complications: : Adrienne Scott, Morton Goldberg 22. Rare presentations and emerging complications: Frédéric Galacteros, Oswaldo Castro, Kathryn Hassell 23. Globalburden of disease: new frontiers in SCD research and care: Kwaku Ohene-Frempong, Julie Makani, Fernando Costa, Graham Serjeant,Yazdi Italia III. EmergingTherapeutics: Overview: David Rees, Sophie Lanzkron 24. Transfusion medicine: Anoosha Habibi, Darrell Triulzi, Miguel Abboud, Sally Campbell Lee 25. Clinical trials - state of the art and lessons learned: Ken Ataga, Laura De Castro, Marilyn Telen 26. Stem cell transplantation: John Tisdale,Courtney Fitzhugh, Mark Walters, Lakshmanan Krishnamurti 27. Emergency care - challenges and opportunities: ClaudiaMorris 28. The psychosocial burden in SCD: MarciaTreadwell, Allison King, Julie Panepinto, Charles Jonaissant 29. Hydroxyurea and the dawn of combination therapy in SCD: Winfred Wang, Russell Ware 30. The HOLY GRAIL - Gene editing and Therapy: TimTownes, Marina Cavazzana-Calvo Additional authors: Joshua Field (chapter assignment TBD)
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