This book is an attempt to build a comprehensive monograph of our recent research articles about synthetic biomedical indoles. It includes two parts: first part written by Dr. El Sayed and second part written by Dr. El Sherif. The subject of this book has become a significant publication for anyone interested in synthesis and biomedical applications of the well known organic compound indole. The monograph provides a permanent dealing with recent synthetic approach of indole containing compounds along with their applications in medicinal chemistry as anticancer agents and antibiotics.