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In the recent years work has become more and more taxing and the stress induced escalates correspondingly. Combine that with a profession that breathes in illness and death, the marshes get murkier. This study was conducted to evaluate the impact of selected determinants of stress on the job satisfaction levels of the nursing staff. The target were the nurses of private hospitals in Islamabad, the capital of Pakistan. The stress determinants in the study were; Responsibility Pressures, Role Conflict, Job vs. Non-Job factors and Workload. The aim of this study is to highlight the problem areas which would allow the management to focus on improving the work conditions of the care-givers. Further, this area of study has a great potential for further research on other dimensions of stress with different sets of samples from the private to the public and across the geography of Pakistan.