Designed as a practical, succinct guide, for quick reference by clinicians with everyday questions, this title guides the reader through the range of approaches available for diagnosis, management, or prevention of hemorrhagic and thrombotic diseases or disorders. _ Provides essential practical management for all those working in the field of hemostasis and thrombosis _ Includes new chapters on direct oral anticoagulants, acquired inhibitors of coagulation, and expanded discussion of thrombotic microangiopathies _ Covers in a clear and succinct format, the diagnosis, treatment and prevention…mehr
Designed as a practical, succinct guide, for quick reference by clinicians with everyday questions, this title guides the reader through the range of approaches available for diagnosis, management, or prevention of hemorrhagic and thrombotic diseases or disorders. _ Provides essential practical management for all those working in the field of hemostasis and thrombosis _ Includes new chapters on direct oral anticoagulants, acquired inhibitors of coagulation, and expanded discussion of thrombotic microangiopathies _ Covers in a clear and succinct format, the diagnosis, treatment and prevention of thrombotic and haemostatic disorders _ Follows templated chapter formats for rapid referral, including key points and summary boxes, and further reading _ Highlights controversial issues and provides advice for everyday questions encountered in the clinic
Nigel S. Key, Harold R. Roberts Distinguished Professor, Division of Hematology and Oncology, Department of Medicine, University of North Carolina School of Medicine, North Carolina, Chapel Hill, USA Michael Makris, Senior Lecturer in Haematology, Department of Medicine and Pharmacology, University of Sheffield, Sheffield, UK David Lillicrap, Professor of Hematology, Department of Pathology and Molecular Medicine, Richardson Laboratory, Queen's University, Kingston, Ontario, Canada
Inhaltsangabe
List of Contributors ix
1 Basic Principles Underlying Coagulation 1 Dougald M. Monroe
2 Laboratory Tests of Hemostasis 12 Steve Kitchen and Michael Makris
3 Molecular Diagnostic Approaches to Hemostasis 27 Paula James and David Lillicrap
4 Tests of Platelet Function 42 Marie Lordkipanidzé, Gillian C. Lowe and Paul Harrison
5 Evaluation of the Bleeding Patient 63 Alice Ma and Marshall Mazepa
6 Hemophilia A and B 79 Rhona M. Maclean and Michael Makris
7 Von Willebrand disease 94 Giancarlo Castaman, Alberto Tosetto and Francesco Rodeghiero
8 The Rarer Inherited Coagulation Disorders 113 Paula H.B. Bolton?-Maggs, Jonathan Wilde and Gillian N. Pike
9 Acquired Inhibitors of Coagulation 124 Riitta Lassila and Elina Armstrong
10 Quantitative Platelet Disorders 134 Riten Kumar and Walter H.A. Kahr
11 Qualitative Platelet Disorders 160 Eti A. Femia Gian Marco Podda and Marco Cattaneo
12 Disseminated Intravascular Coagulation 172 Raj S. Kasthuri and Nigel S. Key
13 Thrombotic Microangiopathies 183 Marie Scully and David Kavanagh
14 Venous Thromboembolism 195 Sarah Takach Lapner, Lori-Ann Linkins and Clive Kearon
15 Myeloproliferative Neoplasms: Thrombosis and Hemorrhage 210 Brandi Reeves and Stephan Moll
16 Arterial Thrombosis 229 R. Campbell Tait and Catherine N. Bagot
17 Anticoagulation: Heparins and Vitamin K Antagonists 240 Gualtiero Palareti and Benilde Cosmi
18 The Direct Oral Anticoagulants 253 David A. Garcia, Mark A. Crowther and Walter Ageno
19 Antiphospholipid Syndrome 269 Henry G. Watson and Mark Crowther
20 Cardiovascular Medicine 282 Sreekanth Vemulapalli and Richard C. Becker
21 Cardiothoracic Surgery 299 Denise O'Shaughnessy and Ravi Gill
22 Neurology 314 Michael Wang, Natalie Aucutt-Walter, Valerie L. Jewells and David Y. Huang
23 Hepatology 329 Lara N. Roberts, Raj K. Patel and Roopen Arya
24 Nephrology 340 Vimal K. Derebail and Thomas L. Ortel
25 Oncology 355 Anna Falanga and Marina Marchetti
26 Obstetrics, Contraception, and Estrogen Replacement 379 Amy Webster and Sue Pavord
27 Pediatrics 393 Mary E. Bauman, Aisha Bruce and M. Patricia Massicotte
28 Intensive and Critical Care 414 Beverley J. Hunt
29 Transfusion 433 Adrian Copplestone
Appendix 1 Reference Ranges 444 Steve Kitchen and Michael Makris
