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This study introduce quick, reliable and reproducible prognostic and diagnostic tool for Colorectal and Breast cancer patients coupling serum TGF-_1 level to quantitative gene expression in blood samples. Serum TGF-_1 level previously reported significance as a diagnostic, prognostic and even therapeutic decisive tool is confirmed showing significant correlation to solid tumor type and size. Blood TGF-_1 quantitative gene expression is offered as an easy, quick and reproducible tool ensuring serum TGF-_1 level reliability.