The work of two leading researchers, this monograph summarizes significant discoveries concerning endothelium-dependent hyperpolarizations, which have led to recent advances that are likely to play a much more important role in cardiovascular physiology and pathology than was originally foreseen. Highlighting 25 years of research, the book offers new insight into the subject. Extensively illustrated with original diagrams and schematics that summarize the different steps of endothelium-dependent hyperpolarization, the text is designed for vascular biologists, and cardiologists, as well as graduate students looking to gain an understanding of the intimate functioning of the blood vessel wall.