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This issue of Clinics in Plastic Surgery, guest edited by Drs. Jin Bo Tang and Michel Saint-Cyr, is devoted to Microsurgery: Global Perspectives. Articles in this issue include: Digital Replantation: Current Status in the World; Exploring New Frontiers of Microsurgery: From Anatomy to Clinical Methods; Free Flaps, Toe Transfers and Microsurgery for Crush Injury in the Hand; Vascularised Bone Grafting for Scaphoid and Lunate Diseases; Vascularised Small Bone Grafting to Treat Scaphoid Non-Union: Outcomes; Compound or Specially Designed Flaps and Other Tissue Transfers in Upper and Lower Extremities; Special Considerations in Upper and Lower Extremity Pediatric Microsurgical Reconstruction; Microsurgical Tissue Transfer in Breast Reconstruction; Non-abdominal Based Free and Pedicle Flaps in Autologous Breast Reconstruction; Complex Microsurgical Reconstruction after Tumor Resection in the Trunk and Extremities; Keystone and Pedicle Perforator flaps in Sarcoma Reconstruction: New Modifications and Applications; Innovations and Future Directions in Head and Neck Microsurgical Reconstruction; New Frontiers in Robotic Assisted Microsurgical Reconstruction; and Current Methods to Deal with Vascular Crisis After Microsurgery: A Global View.