Etiopathogenesis of Systemic Sclerosis: role of human Parvovirus B19 - Colaci, Michele
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Systemic sclerosis, one of the most obscure rheumatic autoimmune diseases, is characterized by endothelial dysfunction and activation of fibroblasts, leading to diffuse microangiopathy and fibrosis of skin and visceral organs. Parvovirus B19,the virus responsable of the Fifth Disease, may infect also endothalial cells and their bone marrow precursors, along with fibroblasts; moreover, it has been associated to several autoimmune disorders, among which also systemic sclerosis. Is there a role for the virus in the etiopathogenesis of systemic sclerosis?

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Produktbeschreibung
Systemic sclerosis, one of the most obscure rheumatic autoimmune diseases, is characterized by endothelial dysfunction and activation of fibroblasts, leading to diffuse microangiopathy and fibrosis of skin and visceral organs. Parvovirus B19,the virus responsable of the Fifth Disease, may infect also endothalial cells and their bone marrow precursors, along with fibroblasts; moreover, it has been associated to several autoimmune disorders, among which also systemic sclerosis. Is there a role for the virus in the etiopathogenesis of systemic sclerosis?
Autorenporträt
Colaci, MicheleDr Michele Colaci, born in 1977, is an Italian rheumatologist, assistant professor at the Rheumatology Unit of the Universitary-based Hospital "Policlinico di Modena", Modena, Italy.Doctoral degree in Clinical and Experimental medicine, University of Modena, in January 2008. Expertise in treatment of autoimmune disorders, particularly scleroderma.