Jie Jack Li, Minmin Yang

Drug Discovery with Privileged Building Blocks (eBook, PDF)

Tactics in Medicinal Chemistry

• Format: PDF

Produktbeschreibung

Drug Discovery with Privileged Building Blocks traces back PharmaBlock's founding philosophy of designing privileged building blocks. Each chapter may be read and studied without learning the previous chapters. This book will be a good starting point for novice medicinal chemists and veteran medicinal chemists find it useful as well.

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Produktdetails

• Verlag: Taylor & Francis
• Seitenzahl: 320
• Erscheinungstermin: 21. Oktober 2021
• Englisch
• ISBN-13: 9781000416015
• Artikelnr.: 62549116

Autorenporträt

Dr. Jie Jack Li is an established chemist with over 20 years of experience in both medicinal chemistry and process chemistry. He is also widely published as an author or co-author of 34 peer-reviewed articles, 12 patents, and 29 books. Prior to joining ChemPartner, Dr. Li worked at Pfizer, BMS, and Revolution Medicines in oncology, antivirals, metabolic disease, CNS, anti-inflammatory, and dermatology, targeting enzymes, receptors, or ion channels. Dr. Li was also a professor at the University of San Francisco for four years, teaching organic and medicinal chemistry. He earned his Ph.D. from Indiana University and was a post-doctoral fellow at MIT.

Dr. Minmin Yang received his PhD in organic synthesis from Auburn University, US in 2001, and did post-doctoral training at the same school from 2002 to 2004. Prior to founding PharmaBlock, he worked with increasing responsibilities from group leader to section head of medicinal chemistry at Roche Palo Alto and Roche China for 4 years. Dr. Yang has authored 80 publications, including 16 international patents.

Inhaltsangabe

Preface 1. Alkynes
2. Azaindoles
3. Azetidines
4. Bicyclic Pyridines Containing Ring-junction N
5. Bicyclo (1.1.1)pentyl (BCP) as an sp3 Carbon-rich Bioisostere for para-Phenyl and tert-Butyl Groups
6. Bicyclo[2.2.2]octane (BCO) as A 3D-rich Bioisotere for the para-Phenyl Group
7. Bicyclo[3.1.0]hexanes
8. Bridge-Fused Rings as m-Phenyl Bioisosteres
9. Cubanes, Are We There Yet?
10. Cyclobutanes
11. Cyclohexanes
12. Cyclopentanes
13. Cyclopropanes as Metabolically More Robust Bioisoteres for Linear Alkyl Substituents
14. Deazapurines
15. Furopyridines
16. Indazoles
17. Indoles
18. Oxetanes
19. Piperidine, the Enchanted Ring
20. Pyrazines
21. Pyrazoles
22. Pyridazines
23. Pyridines - The Magic of Phenyl-Pyridyl Switch
24. Pyrimidines
25. Pyrrolidines
26. Pyrrolotriazines
27. Spiroazetidines
28. Spirocyclic Piperidines
29. Spirocyclic pyrrolidines
30. Spirooxetanes
31. Tetrahydropyrans
32. Trifluoromethylpyridines. Index