Cyclisation / Desymmetrisation Reactions of Cyclohexa-1,4-Dienes - El-Sayed, Nahed
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This work describes different strategies to desymmetrise 1,4-cyclohexadiene derivatives with concomitant formation of a quaternary stereogenic centre. Chapter 1 briefly describes the previous desymmetrisation processes of 1,4-cyclohexadiene derivatives. Chapter 2 describes the formation of the quaternary stereogenic centre using achiral cyclohexa-1,4-dienone derivatives. Stereoselective formation of a quaternary stereogenic centre was achieved using a chiral sulfinyl group as the stereodirecting influence during the cyclisation step. Chapter 3 outlines attempts to improve the level of…mehr

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Produktbeschreibung
This work describes different strategies to desymmetrise 1,4-cyclohexadiene derivatives with concomitant formation of a quaternary stereogenic centre. Chapter 1 briefly describes the previous desymmetrisation processes of 1,4-cyclohexadiene derivatives. Chapter 2 describes the formation of the quaternary stereogenic centre using achiral cyclohexa-1,4-dienone derivatives. Stereoselective formation of a quaternary stereogenic centre was achieved using a chiral sulfinyl group as the stereodirecting influence during the cyclisation step. Chapter 3 outlines attempts to improve the level of sulfoxide mediated diastereoselectivity. Chapter 4 describes the desymmetrisation of the two diastereotopic double bonds of cyclohexa-1,4-diene derivatives using free-radical methodology Chapters 5 describes the desymmetrisation of the two diastereotopic double bonds of 1,4-cyclohexadiene derivatives using Prins cyclisation reaction. This approach afforded an easy and stereocontrolled access to fused tetrahydropyrans and tetrahydrofurans depending on the reaction conditions employed. The stereochemical outcome of all of these reactions was rationalized by a single transition state model.
Autorenporträt
Nahed Nasser E. El-Sayed, B.Sc. Biochemistry with Chemistry and M.Sc. in Organic Chemistry Faculty of Science, Ain Shams University, Cairo, Egypt. PhD in Synthetic Organic Chemistry: School of Chemistry, Cardiff University, UK. Assistant Professor of Organic Chemistry, Department of Chemistry, College of Science, King Saud University, KSA.