Millets are versatile in tolerating to diverse climatic and soil conditions such as poor soil fertility and moisture deficit. Establishing optimum regeneration method for each millet type and ecotype is a pre-requisite prior to embarking on plant transformation as successes in plant transformation is largely dependent on the efficiency of regeneration. Various studies made to identify optimum regeneration and transformation methods as well as prospects of applying advanced techniques to these vital but under-studied crops of developing world are discussed.