Reactivity of cyclododecanone in aldol and Mannich-Type reactions - Venkatesan, Sathesh;Kulathu Iyer, Sathiyanarayanan
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In this book we address, cyclododecanone as a substrate-controlled precursor. Its, unique activation strategy, acting cooperatively with Lewis based or Lewis acid groups, has been applied to the development of a novel generation of cyclododecanone based compounds. The viability of the catalyst under optimized reaction condition was established for all the title reactions. Extended mechanistic pathways lead to the suggestion of a catalytic cycle in which highly preferred transition state plays a major role for both yield and diastereoselectivity for the reactions. Finally, strategies were…mehr

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Produktbeschreibung
In this book we address, cyclododecanone as a substrate-controlled precursor. Its, unique activation strategy, acting cooperatively with Lewis based or Lewis acid groups, has been applied to the development of a novel generation of cyclododecanone based compounds. The viability of the catalyst under optimized reaction condition was established for all the title reactions. Extended mechanistic pathways lead to the suggestion of a catalytic cycle in which highly preferred transition state plays a major role for both yield and diastereoselectivity for the reactions. Finally, strategies were employed to further examine asymmetric induction reaction in cyclododecanone using proline as a catalyst, but we could not achieve goals at present conditions. Even unmodified ketone like propiophenone the stereochemistry has been thoroughly investigated. Whereas, higher cyclic ketones like 9-12 membered ring cyclic ketones the stereochemistry has not been studied so far. The aim of our work is to studied the reactivity of CDD in aldol sequences and Mannich-type reaction in direct manner and to know the stereochemical behavior of higher ring ketones.
Autorenporträt
Sathesh Venkatesan was born in Vellore, India. Where he is lived in Palappadi village. He received his undergraduate degree in Chemistry at Muthurangam Govt. Arts College, Vellore. After a brief stint in the chemistry postgraduate program & doctoral studies at VIT University under the direction of Professor Dr. K. Sathiyanarayanan.