Clear cell changes may be observed in virtually any benign or malignant tumor of epithelial, mesenchymal, melanocytic and hematopoeitic derivation not be attributed to variable etiologies. In general, clear cell neoplasms of the head and neck are rare. They may involve various regions and may be of diverse derivations, and are primarily or almost exclusively composed of clear cells. This book will selectively discuss the clinicopathological features of with clear cell changes, which, at times, may pose a diagnostic challenge and dilemma.