Myofascial Pain Dysfucntion Syndrome is a heterogeneous group of signs and symptoms that affect the jaw joint and/or the chewing musculature. Myofascial pain syndrome (MPS) is defined as pain that originates from myofascial trigger points in skeletal muscle. It is prevalent in regional musculoskeletal pain syndromes, either alone or in combination with other pain generators like Temporomandibular disorders (TMD). The appropriate evaluation and management of myofascial pain is an important part of musculoskeletal rehabilitation, and regional axial and limb pain syndromes. Currently a multifactorial theory on MPDS has received a great support among the scientific community. Myofascial Pain is the most common form of TMD, affecting principally women in reproductive age.