The purpose of this study was to determine the activities of antioxidants such as GSH, ascorbic acid, protein oxidation, calcium and antioxidant enzymes such as GPx, GR, GST, AR, SD in diabetic and nondiabetic cataractous lenses and to designate the role of these enzymes in the development of diabetic cataract.The present book leads to the conclusion of increased oxidative stress as the cataract advances with decreased antioxidant capacity. In order to overcome the oxidative Stress, the exogenous compounds taken concurrently are beneficial for the prevention of cataract. In addition the endogenous antioxidants may also reduce the adverse effects of cataract.