While the vast literature on sustainable transport emphasizes certain urban development patterns as those that should be encouraged in urban planning, it is a fact that there is an increasing tendency in many urban areas in the world towards becoming a city-region. However, whether these city-region development patterns can help attain a more sustainable urban growth and transport system is a relatively less studied area in the field of sustainable transport. In general terms, the study aims to bring together these two important fields of research in the planning literature: sustainable transport and city-regions, with a view to analyze whether they can co-exist, whether their policies comply with, and complement each other, eventually whether it is possible to attain transport sustainability in city-regions.