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yi dao su di kang shi you fa xing tang niao bing dai xie zong he zheng he fei pang deng de zhu yao yuan yin yi dao su di kang you xu duo yin su yin qi er yi dao su xin hao chuan di shou zu huo jian ruo shi dao zhi yi dao su di kang fa sheng de zhu yao yuan yin zhi yi SOCS3 shi xi bao yin zi xin hao zhuan dao yi zhi yin zi suppressor of cytokine signaling SOCS jia zu de cheng yuan zhu yao can yu fu diao kong sheng chang ji su bai xi bao jie su 1 IL 1 IL 2 IL 6 zhong liu huai si yin zi TNF gan rao su IFN he shou su deng xi bao yin zi de xin hao zhuan dao zui jin de yan jiu biao ming SOCS3 neng gou yi zhi yi dao su xin hao tong lu zai yi dao su di kang de fa sheng fa zhan zhong ju you shi fen zhong yao de diao kong gong neng zhu zai sheng li sheng hua te dian he yi chuan shang yu ren ju you gao du de xiang si xing shi yan jiu ren lei fei pang he xing tang niao bing de li xiang dong wu mo xing yin ci ben yan jiu yi 1 3 ri ling zi zhu yuan dai pei yang de zhi fang xi bao wei yan jiu dui xiang shou xian jian ce le 100 nM de yi dao su dui zhi fang xi bao fen hua ji SOCS3 mRNA he dan bai biao da de ying xiang qi ci tong guo gou jian SOCS3 ji yin de zhong zu xian bing du zai ti gan ran fen hua de zhi fang xi bao zai zhi fang xi bao zhong chao biao da SOCS3 hou RT PCR he Western blotting jian ce bing fen xi le zhi fang xi bao zhong SOCS3 ji yin ji yi dao su xin hao tong lu zhu yao xin hao fen zi de biao da ji lin suan hua shui ping chu bu tan tao le SOCS3 zai zhu zhi fang xi bao yi dao su xin hao tong lu zhong de zuo yong