Taste Masking and Formulation of Ondansetron Mouth Dissolving Tablets - Poudel, Bhupendra Kumar;Subdei, Shyam Raj;Thapa, Panna
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The present work is an attempt to design mouth dissolving tablets of Ondansetron hydrochloride. Drug Resin Complex was formulated by direct compression into mouth dissolving tablet using microcrystalline cellulose PH 102, as diluent and croscarmalose sodium and sodium starch glycolate as superdisintegrants while aspartame was used as sweetening agent to enhance palatability. Taste masking was done by using polacrilex resin Tulsion 335. The prepared formulation can be useful for patients who have swallowing difficulty.

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Produktbeschreibung
The present work is an attempt to design mouth dissolving tablets of Ondansetron hydrochloride. Drug Resin Complex was formulated by direct compression into mouth dissolving tablet using microcrystalline cellulose PH 102, as diluent and croscarmalose sodium and sodium starch glycolate as superdisintegrants while aspartame was used as sweetening agent to enhance palatability. Taste masking was done by using polacrilex resin Tulsion 335. The prepared formulation can be useful for patients who have swallowing difficulty.
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Autorenporträt
Bhupendra Kumar Poudel, Shyam Raj Subedi, Panna Thapa, Uttam Budhathoki, Bhupendra Kumar Poudel, Shyam Raj Subedi completed their Master of Pharmacy from Kathmandu University. Panna Thapa and Uttam Budthathoki supervised this contribution.