Heba Kamal Nabih, Shadia Abdel-Hamid Fathy

Telomere Length and Drug Resistance Related Proteins in Astrocytomas

To minimize the useless doses of therapy in necessary cases

• Broschiertes Buch

Produktbeschreibung

Gliomas are the most common primary brain tumors and have a poor prognosis. Traditionally they were managed with resection and radiotherapy but chemotherapy is assuming an increasingly important role. Only a small sub-set of patients benefit from chemotherapy however, due to the multidrug resistance phenomenon. Tumors may have an endogenous drug resistance, or may develop resistance to previously effective therapeutic agents to which they have been exposed. It has been proposed that the ATP-dependent drug efflux channel, P-glycoprotein (P-gP), Survivin, Telomere and the mutation in P53 protein; affect chemoresistance in cancer cells. Moreover, traditional method for subgrouping patients into various prognostic groups by histomorphologic grading has been subjective and unreliable in predicting the prognosis of individual patients. Thus, there is a need for more sophisticated prognostic determinants.

Produktdetails

• Verlag: LAP Lambert Academic Publishing
• Seitenzahl: 176
• Erscheinungstermin: 8. Februar 2013
• Englisch
• Abmessung: 220mm x 150mm x 11mm
• Gewicht: 280g
• ISBN-13: 9783659341571
• ISBN-10: 3659341576
• Artikelnr.: 37222178

Autorenporträt

Heba Kamal Nabih Hanafi- Investigador no Departamento de Bioquímica Médica - Divisão de Investigação Médica - Centro Nacional de Investigação - Dokki, Giza - Egipto. Doutoramento em Bioquímica (2017) - Departamento de Bioquímica - Faculdade de Ciências - Universidade Ain Shams - Cairo - Egipto.