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Transdermal delivery offers several biomedical advantages over conventional routes including avoidance of presystemic and systemic first pass metabolism and controlled release over extended period Physical enhancement mechanisms including here are iontophoresis, electro- poration, ultrasound, photomechanical waves, magnetophoresis, microfabricated microneedles, radiofrequency-driven skin microchanneling and transferosomes.Iontophoresis is being explored for drugs whose delivery is not benefited by chemical enhancer. Sonophoresis is a process that exponentially increases the absorption of topical compounds into the epidermis, dermis and skin appendages by ultrasonic energy. A Transfersomes possess an infrastructure consisting of hydrophobic and hydrophilic moieties together and as a result can accommodate drug molecules with wide range of solubility.