This book provides an insight to the calculus inhibiting agents dating from the 19th century to the latest agents. An effort has been made to elicit a detailed description ranging for the chemical structure, physical properties, mechanisms of action, literature supporting the use of the agents and most importantly adverse effects of these agents. Our aim is to make the read as intersting as possible through this project. Being my maiden project I hope its read by one and all. Critic reviews are most welcome.