The restoration of aesthetics in patient with gross defects of the face and head is a valuable and often dramatic service provided by maxillofacial prosthodontist. The replacement of missing parts such as nose, eye, ear or the construction of a device to rebuild facial or cranial contour requires the utmost in clinical skill and utilisation of available materials. Rehabilitation of patients with maxillofacial defects has always remained an enigma for the prosthodontist due to the unpredictable nature of the defects and uncertainty of recurrence.An attempt has been made to review to prosthetic aspects of the rehabilitation of the patients with palato- maxillary defects with a strong emphasis on the understanding of the anatomical and physiological considerations and the psychosocial well-being of the patient.