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This issue presents the views of internationally renowned experts on current findings concerning the epidemiology, natural history, diagnosis, pathogenesis, and treatment of non-alcoholic steatohepatitis. Articles are included on bariatric surgery, liver transplantation, cytokines and apoptosis, as well as insulin resistence and lipotoxicity, to name a few. The Guest Editor himself ends the issue with an article giving his overall perspective on the current clinical management of NASH and future directions.