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V knige dan obzor sovremennyh predstavlenij o tyazhelom sepsise i septicheskom shoke. Pokazany rezul'taty soglasitel'nyh konferencij po klassifikacii sepsisa u vzroslyh i detej. Otrazheny pokazateli smertnosti v gruppe bol'nyh s septicheskim techeniem. Rassmotreny osnovnye zven'ya patogeneza sepsisa, takie kak bakteriemiya, mikrobnaya toxemiya, jendo(auto)toxikoz, sistemnyj destruktivnyj vaskulit, narastajushhaya giperkoagulyacii s perehodom v koagulopatiju, trombocitopeniya potrebleniya s trombogemorragicheskim sindromom i tyazhelaya immunosupressiya. Patogenez septicheskogo shoka razdeljon na processy, proishodyashhie v organah i tkanyah, a takzhe na processy, proishodyashhie vnutrikletochno: oxidativnyj stress i mitohondrial'naya nedostatochnost'. Vydelena rol' patogen -associirovanyh molekulyarnyh obrazov: "patternov" v razvitii generalizovannogo aciklichnogo infekcionnogo processa. Pokazana shema sovremennoj terapii septicheskogo shoka. Vyyavlena vazhnaya rol' oxida azota v razvitii stojkoj gipotonii, ploho poddajushhejsya vazopressornoj podderzhke.