Pharmacogenomic Effect on Biopharmaceutics of Anti-Tubercular Therapy - Modgil, Swati;Thakur, Shivani;Rana, Rajat
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The first line anti-tuberculosis drugs are known to cause dose related adverse drug reactions like peripheral neuritis and hepatotoxicity. The risk of getting peripheral neuritis have been avoided through a concomitant administration of pyridoxine; while hepatotoxicity remains to be a major adverse effect of anti- tuberculosis therapy. Research findings state reduction in the incidence of hepatotoxicity by exploring a potential link between biopharmaceutical pattern of anti-tuberculosis drugs and genetic polymorphism of the enzymes metabolizing them. Reportedly a significant correlation has been found by pooling the data through a meta-analysis.…mehr

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Produktbeschreibung
The first line anti-tuberculosis drugs are known to cause dose related adverse drug reactions like peripheral neuritis and hepatotoxicity. The risk of getting peripheral neuritis have been avoided through a concomitant administration of pyridoxine; while hepatotoxicity remains to be a major adverse effect of anti- tuberculosis therapy. Research findings state reduction in the incidence of hepatotoxicity by exploring a potential link between biopharmaceutical pattern of anti-tuberculosis drugs and genetic polymorphism of the enzymes metabolizing them. Reportedly a significant correlation has been found by pooling the data through a meta-analysis.
Autorenporträt
Ms. Swati Modgill is an academician and researcher in the field of development and characterization of biopharmaceuticals. She also prestigious member of various pharmaecutial associations. Ms. Shivani Thakur is a well known scientist and academician with vast research experience over 8 years on Central Nervous system related anomlaies.