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The objective of this book is to present the strategies employed by living organisms on a molecular level and to help understand the basics of Systems Biology. Its content is organized in a way to meet the exponential growth in the volume of biological knowledge, and the need for a multidisciplinary approach in the practice of teaching modern biology. For this reason, the whole material is divided into five chapters, each devoted to a fundamental concept: Structure-Function, Energy, Information, Regulation and Interrelationships. The book describes generic mechanisms which occur in biology and…mehr
The objective of this book is to present the strategies employed by living organisms on a molecular level and to help understand the basics of Systems Biology. Its content is organized in a way to meet the exponential growth in the volume of biological knowledge, and the need for a multidisciplinary approach in the practice of teaching modern biology. For this reason, the whole material is divided into five chapters, each devoted to a fundamental concept: Structure-Function, Energy, Information, Regulation and Interrelationships. The book describes generic mechanisms which occur in biology and promotes a simulation-based approach to the subject of Systems Biology. The use of basic knowledge as the background for presenting biological problems obligates the teachers to deal with generalized phenomena comprising the ever increasing volume of teaching materials. This book is intended for biologists and is informative for specialists in the areas of computer science, robotics and engineering.
Prof. emeritus Leszek Konieczny, MD, is Professor of Biochemistry at the Medical College of Jagiellonian University, Poland. His background is in medicine and his research focuses on immunochemistry and target-oriented drug transport. He is the author of numerous scientific papers in the field of protein structure, function and immunochemistry. He teaches biochemistry to medical students and has authored several textbooks on systems biology and protein structure. Prof. Irena Roterman-Konieczna, PhD, is Professor of Medical Sciences at the Medical College of Jagiellonian University, Poland. Her background is in bioinformatics and theoretical chemistry. She was included in 2020, 2021 and 2022 on the Stanford World Ranking Top 2% Scientists. Her scientific interests focus on protein structure, function and amyloidosis. She is involved in numerous international scientific collaborations and is the Polish Chief of the EuChinaGrid network. She has authored highly successful textbooks for medical and life sciences students interested in learning about simulations in medicine, bioinformatics, statistics and systems biology. Pawe¿ Spólnik, MD, PhD, obtained his PhD in 2005 at the Medical College, Jagiellonian University, Poland. He studied medicine at the Faculty of Medicine of Jagiellonian University and specialised in internal medicine and cardiology. Currently, he works as an Interventional Cardiologist in Germany.
Inhaltsangabe
The Structure and Function of Living Organisms.- General physiochemical properties of biological structures.- Self-organization.- Hypothesis - Protein folding simulation hypothesis - late stage intermediate – role of water.- Energy in Biology – Demand and Use.- General principles of thermodynamics.- Biological energy sources – synthesis of water.- ATP synthesis.- Photosynthesis.- Direct and indirect exploitation of energy sources.- Energy conversion efficiency in biological processes.- Entropic effects.- Energy requirements of organisms.- Information – Its Role and Meaning in Organisms.- Information as a quantitative concept. - Reliability of information sources.- Types of information conveyed by DNA.- Information entropy and mechanisms assisting selection.- The role of information in interpreting pathological events.- Hypothesis - Protein folding early stage intermediate.- Regulation in Biological Systems.- The cell and the organism.- The principle and mechanism of automatic intracellular regulation.- Regulatory coupling between cells and organisms – hierarchical properties of regulation.- Regulatory mechanisms on the organism level.- Basic principles of regulation in biology.- Regulation levels.- Hypothesis - Proteome construction hypothesis.- Interrelationships in Organized Biological Systems.- The need of mutual relations in biological systems.- Cooperation and coordination.- The characteristics of process coordination in individual cells and organisms.- Mutual relationship between cells and the organism – activation and inhibition of enzymes (rapid effects).- Mutual support between cells and the organism – interdependence related to gene expression (slow effects).- Specialization of cell interrelationships.- Hypothesis - The criteria of life.
Chapter 1: The Structure And Function Of Living Organisms.- Chapter 2: Energy In Biology - Demand And Use.- Chapter 3: Information - Its Role And Meaning In Organism.- Chapter 4: Regulation In Biological Systems.- Chapter 5: Interrelationship In Organized Biological Systems.
The Structure and Function of Living Organisms.- General physiochemical properties of biological structures.- Self-organization.- Hypothesis - Protein folding simulation hypothesis - late stage intermediate – role of water.- Energy in Biology – Demand and Use.- General principles of thermodynamics.- Biological energy sources – synthesis of water.- ATP synthesis.- Photosynthesis.- Direct and indirect exploitation of energy sources.- Energy conversion efficiency in biological processes.- Entropic effects.- Energy requirements of organisms.- Information – Its Role and Meaning in Organisms.- Information as a quantitative concept. - Reliability of information sources.- Types of information conveyed by DNA.- Information entropy and mechanisms assisting selection.- The role of information in interpreting pathological events.- Hypothesis - Protein folding early stage intermediate.- Regulation in Biological Systems.- The cell and the organism.- The principle and mechanism of automatic intracellular regulation.- Regulatory coupling between cells and organisms – hierarchical properties of regulation.- Regulatory mechanisms on the organism level.- Basic principles of regulation in biology.- Regulation levels.- Hypothesis - Proteome construction hypothesis.- Interrelationships in Organized Biological Systems.- The need of mutual relations in biological systems.- Cooperation and coordination.- The characteristics of process coordination in individual cells and organisms.- Mutual relationship between cells and the organism – activation and inhibition of enzymes (rapid effects).- Mutual support between cells and the organism – interdependence related to gene expression (slow effects).- Specialization of cell interrelationships.- Hypothesis - The criteria of life.
Chapter 1: The Structure And Function Of Living Organisms.- Chapter 2: Energy In Biology - Demand And Use.- Chapter 3: Information - Its Role And Meaning In Organism.- Chapter 4: Regulation In Biological Systems.- Chapter 5: Interrelationship In Organized Biological Systems.
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