Design & Evaluation of Controlled Release Matrix Tablets of Prazosin - Kothari, Rajan;Sharma, Gaurav Kumar;Atul Tiwari, Pankaj Chasta
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In the present study, we have prepared matrix tablet formulations using Prazocin as a model drug and Ethyl Cellulose, Two grades of Hydroxy Propyl Methyl Cellulose- HPMC-K4M & HPMC-K100M as polymers in different ratios. The developed matrix tablets were evaluated for different physical-chemical evaluations like drug content, hardness, friability, swelling index etc. All the formulations had shown the results within prescribed limits. The In vitro drug release study indicates that formulation PCF-7 containing EC, HPMC K100M in 1:2 ratio shown good release pattern for 14 hours compares to other…mehr

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Produktbeschreibung
In the present study, we have prepared matrix tablet formulations using Prazocin as a model drug and Ethyl Cellulose, Two grades of Hydroxy Propyl Methyl Cellulose- HPMC-K4M & HPMC-K100M as polymers in different ratios. The developed matrix tablets were evaluated for different physical-chemical evaluations like drug content, hardness, friability, swelling index etc. All the formulations had shown the results within prescribed limits. The In vitro drug release study indicates that formulation PCF-7 containing EC, HPMC K100M in 1:2 ratio shown good release pattern for 14 hours compares to other formulations. The short-term stability study proved no change in the formulation of ageing and it indicates good stability.
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Autorenporträt
Mr. Rajan Kothari, M.Pharm.(Pharmaceutics), Rajiv Gandhi University of Health Sciences, Bangalore, Karnataka, India. Assistant Professor at Faculty of Pharmaceutical Sciences, Mewar University, Gangrar, Chittorgarh-312901, Rajasthan, India