Peter K Gessner, P K Gessner, Gessner

Disulfiram and Its Metabolite, Diethyldithiocarbamate

Pharmacology and Status in the Treatment of Alcoholism, HIV Infections, AIDS

• Gebundenes Buch

Produktbeschreibung

This book provides a critical review of the current state of research on the properties, pharmacology and toxicology of disulfiram and diethyldithiocarbamate and their use for the treatment of a variety of human disease conditions, including cancer, alcoholism and heavy metal toxification.

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Produktdetails

• Verlag: Palgrave MacMillan UK
• Seitenzahl: 476
• Erscheinungstermin: 31. August 1992
• Englisch
• Abmessung: 241mm x 160mm x 31mm
• Gewicht: 875g
• ISBN-13: 9780412360107
• ISBN-10: 0412360101
• Artikelnr.: 24480189

Inhaltsangabe

Introduction and scope of monograph. Relevant chemical and physical
properties. Reactions of disulfiram and diethyldithiocarbamate with blood
constituents. Assay methods for disulfiram and metabolites in biological
materials. Metabolism of disulfiram and diethyldithiocarbamate.
Pharmacokinetic aspects of the disposition of disulfiram and metabolites.
Heavy metals: effects of diethyldithiocarbamate and disulfiram
administration. Disulfiram and diethyldithiocarbamate as enzyme inhibitors.
Inhibition of aldehyde dehydrogenase. The disulfiram-ethanol reaction.
Disulfiram therapy of alcohol abuse. Various biological phenomena.
Immunomodulatory actions of diethyldithiocarbamate. Clinical status of
diethyldithiocarbamate as an immunostimulant. Modulation of various
biological phenomena. Modulation of cancer chemotherapy. Toxicology.
Bibliography. Index.