(Chapter 1) This research aimed evaluates the antitumor activity against the malignant tumor Glioblastoma Multiforme based in extracts from Antarctic seaweeds Iridaea cordata and Desmarestia anceps collected at Peninsula Antarctica. (Chapter 2) Glioblastoma, a grade IV glioma, is a type of primary malignant brain tumor which shows a higher incidence in adults. Because of its poor prognosis, there is an incentive for new drug discovery. Accordingly, knowing the anticancer potential of some compounds isolated from seaweeds, our goal is evaluate the antiglioma activity from endemic Rhodophyta from Antarctica Pyropia endiviifolia.